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NCT Number: NCT07596004

COMPARISON OF DEXMEDETOMIDINE AND NORMAL SALINE IN NEBULIZATION TO BLUNT HEMODYNAMIC RESPONSE

BLUNTING OF HEMODYNAMIC RESPONSE WILL BE OBSERVED IN PATIENTS NEBULISED WITH DEXMEDETOMIDINE AND NORMAL SALINE.

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

HEMODYNAMIC RESPONSETO LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION

Age range

18 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

SMBBIT

Karachi, Sindh, 7500, Pakistan

About this study

ONE GROUP OF PTS WILL BE NEBULISED WITH DEXMEDETOMIDINE AND OTHER WITH NORMAL SALINE AND WILL BE OBSERVED DURING AND AFTER INTUBATION FOR ATTENUATION OF HEMODYNAMIC RESPONSE FOR LYRANGOSCOPY AND ENDOTRACHEAL INTUBATION

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-60 years
  • Either gender
  • ASA Physical Status I and II
  • Mallampati airway class I and II
  • BMI 18-30 kg/m2
  • Patients undergoing elective surgery under general anesthesia

Exclusion criteria

  • Patient refusal or lack of consent
  • Anticipated difficult airway
  • Intubation attempt lasting more than 15 seconds
  • Pregnancy
  • Uncontrolled hypertension, cardiac, pulmonary, hepatic, or cerebral events
  • Known allergy to dexmedetomidine or study drugs

Treatment and study plan

Dexmeditomidine

Drug

dexmeditomidine 1mcg/kg diluted in 5ml 0.9% sodium chloride, administered via nebulizer over 5 minutes, 30 minutes prior to anesthetic induction .

Normal Saline (0.9% Sodium Chloride)

Drug

normal saline 5 ml administered via nebulizer over 5 minutes, 30 minutes prior to anesthetic induction.

Primary outcomes

  1. change in mean artirial pressure and heart rate after lyrangoscopy and intubation

    Time frame: baseline, 1 minute and 3 minute post intubation

    hemodynamic stress response measured as change in mean arterial pressure and heart rate from baseline. MAP and HR will be recorded at baseline T0, 1 minute post intubation T1 ans 3 minute post intubation T3. Significant stress response is defined as rise in MAP nad HR more than 10% of baseline at 3 minutes post intubation.

Sponsors and collaborators

Lead sponsor

Shaheed Mohtarma Benazir Bhutto Institue of Trauma

Other

Registry information

Official study title

Comparison of Nebulised Dexmedetomidine Versus Nebulised Saline Preoperatively To Attenuate Hemodynamic Response to Laryngoscopy and Endotracheal Intubation: A Randomised Control Trial

Acronym: THE

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 19, 2026
Registry last updated
May 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.