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NCT Number: NCT07386470

Comparison of Costoclavicular and Lateral Sagittal Infraclavicular Blocks

This randomized clinical study aims to compare the effects of two different ultrasound-guided infraclavicular brachial plexus block techniques-costoclavicular and lateral sagittal approaches-in patients undergoing forearm, wrist, or hand surgery.

The primary objective of the study is to evaluate and compare the incidence of hemidiaphragmatic dysfunction associated with these two block techniques. Secondary outcomes include sensory and motor block characteristics, postoperative pain scores, analgesic requirements, and potential block-related complications.

Eligible adult patients scheduled for elective forearm or hand surgery are randomly assigned to receive either a costoclavicular or a lateral sagittal infraclavicular nerve block using bupivacaine under ultrasound guidance. Standard general anesthesia and postoperative analgesia protocols are applied.

The results of this study are expected to provide evidence on the relative safety and efficacy of these two infraclavicular block approaches, particularly regarding diaphragmatic function, and to help guide anesthesiologists in selecting the most appropriate regional anesthesia technique for upper extremity surgery.

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Key information

Conditions

Hemidiaphragmatic Paralysis Upper Extremity Surgery

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gazi University Faculty of Medicine, Department of Anesthesiology and Reanimation

Ankara, 06560, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18-80 years
  • ASA physical status I-III
  • Scheduled for forearm, wrist, or hand surgery
  • Planned infraclavicular brachial plexus block

Exclusion criteria

  • Refusal of regional anesthesia
  • Known allergy to local anesthetics
  • Infection at the block site
  • Pre-existing neurological deficit in the operative limb
  • Severe pulmonary disease
  • Coagulopathy or sepsis
  • BMI > 40 kg/m²
  • Psychiatric disorders

Treatment and study plan

Ultrasound-guided infraclavicular block

Procedure

Ultrasound-guided infraclavicular brachial plexus block performed using either the costoclavicular or lateral sagittal approach with standardized local anesthetic volume.

Other names: costoclavicular infraclavicular block, lateral sagital infraclavicular block

Primary outcomes

  1. Diaphragmatic excursion

    Time frame: Baseline(pre-block) and 30 minutes after block performance.

    Diaphragmatic excursion measured by ultrasound during normal and deep breathing to asses the effect of costoclavicular and lateral sagittal infraclavicular block techniques.

Secondary outcomes

  1. Sensory and motor block onset time

    Time frame: Within the first 30 minutes after block performance.

    Time from completion of the infraclavicular block to achievement of complete sensory and motor block in the radial, median, ulnar, and musculocutaneous nerve distributions. Sensory and motor function were assessed every 5 minutes for up to 30 minutes after block performance, and block onset time was defined as the time to complete block.

  2. Time to first postoperative analgesic requirement

    Time frame: Within the first 24 hours postoperatively.

    Time from the end of the surgery to the first analgesic requirement.

Sponsors and collaborators

Lead sponsor

Gazi University

Other

Registry information

Official study title

Effect of Costoclavicular Versus Lateral Sagittal Infraclavicular Block on Hemidiaphragmatic Function: A Randomized Clinical Study

Acronym: CCLS-ICB

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Feb 4, 2026
Registry last updated
Feb 5, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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