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OpenTrials
Completed

NCT Number: NCT01418300

Comparison of Conventional Triple Therapy Versus Sequential Therapy for H. Pylori in Peptic Ulcer Disease: Prospective Randomized Trial

The purpose of this study is to improve first line Helicobacter pylori eradication rate and to compare the sequential versus conventional triple therapy.

Completed

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Key information

Conditions

Helicobacter Infected Patients

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Gil Medical Center

Incheon, South Korea

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • peptic ulcer diseae
  • two test positive rapid urease test, culture, histology

Exclusion criteria

  • lactating or pregnant
  • previous stomach surgery
  • severe underlying disease

Treatment and study plan

sequential versus triple

Drug

sequential: lansoprazole 30mg bid+amoxicillin 100mg bid for first five day lansoprazole 30mg bid+clarithromycin 500mg bid+metronidazole 500mg for 5day conventional tripe lansoprazole 30mg bid+clarithromycin 500mg bid+amoxicillin 1000mg bid

Primary outcomes

  1. the eradication rate by urea breath test

    Time frame: 4-6 week later after completion of therapy

    to compare the eradication rate (intention-to-treat and per protocol) by urea breath test at least four weeks after treatment

Sponsors and collaborators

Lead sponsor

Jun-Won Chung

Industry

Registry information

Important dates

Study start
2010
Primary completion
2011
Study completion
2011
First posted
Aug 17, 2011
Registry last updated
Apr 28, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.