Skip to main content
OpenTrials
Completed

NCT Number: NCT06863181

Comparison of Conventional and Cooled Radiofrequency Ablation in Knee Osteoarthritis

The aim of this study was to examine and compare the effects of conventional and cooled radiofrequency ablation on pain and disability levels in patients with knee pain resistant to other treatments due to knee osteoarthritis.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Knee Osteoarthritis Arthritis Joint Diseases Musculoskeletal Diseases Osteoarthritis Osteoarthritis, Knee Rheumatic Diseases

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gaziler Physical Medicine and Rehabilitation Training and Research Hospital

Ankara, Çankaya, 06800, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Knee pain lasting more than 6 months
  • Age between 50 and 80
  • Diagnosis of radiographically proven grade III or IV knee osteoarthritis according to the Kellgren-Lawrence Grading Scale, marked narrowing of the medial compartment of the tibiofemoral joint space
  • Presence of pain resistant to conservative treatment
  • Exercise
  • Physical therapy agents
  • Use of oral anti-inflammatory agents

Exclusion criteria

  • History of trauma to the knee area
  • History of knee surgery
  • Presence of systemic inflammatory disease affecting the knee joint
  • Presence of peripheral neuropathy or radiculopathy
  • Pregnancy
  • Hemodynamic instability
  • Presence of skin or soft tissue infection at the injection site
  • Refusal to participate in the study
  • Presence of acute knee pain with accompanying inflammatory findings
  • Presence of a serious psychiatric disorder or neurological disease Having received an intra-articular injection within the last 3 months

Treatment and study plan

Radiofrequency Ablation

Device

Genicular nerve neurolysis with heat

Primary outcomes

  1. Visual Analog Scale (VAS)

    Time frame: Before treatment (0. week), 4 weeks after treatment (4.week), 12 weeks after treatment (12.week)

    Patients will select their pain from 10 mm scale

Secondary outcomes

  1. Western Ontario and McMaster Universities Arthritis Index (WOMAC)

    Time frame: Before treatment (0. week), 4 weeks after treatment (4.week), 12 weeks after treatment (12.week)

    This scale about patient's disability due to knee osteoarthritis

  2. 5-Point Likert Patient Satisfaction Scale

    Time frame: Before treatment (0. week), 4 weeks after treatment (4.week), 12 weeks after treatment (12.week)

    '0' =I am not happy at all, '5'=I am very pleased

  3. Change in frequency of analgesic use

    Time frame: Before treatment (0. week), 4 weeks after treatment (4.week), 12 weeks after treatment (12.week)

    How many analgesic did use in past week?

Sponsors and collaborators

Lead sponsor

Gaziler Physical Medicine and Rehabilitation Education and Research Hospital

Other

Registry information

Official study title

Comparison of the Effectiveness of Conventional and Cooled Radiofrequency Ablation in Advanced Knee Osteoarthritis

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Mar 7, 2025
Registry last updated
Feb 27, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.