Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PL-AMD)

The rationale of this research is to determine if patients with lupus and presenting retinal "pseudo-drusen-like" deposits have genetic and complement-related similarities with AMD patients.

Based on the results obtained, this study could lead to future research that could better target the treatment of patients with lupus or patients with AMD (Age related Macular Degeneration).

The primary objective is to check if patients with lupus, treated or not with antimalarial drugs, with "pseudo-drusen-like" deposits have a different complement profile (functional exploration of complement, complement factors, genetic complement polymorphisms involved in AMD) compared to patients without "pseudo-drusen-like" deposits.

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Key information

Conditions

Lupus Erythematosus Age Related Macular Degeneration Autoimmune Diseases Connective Tissue Diseases Eye Diseases Immune System Diseases Lupus Erythematosus, Systemic Macular Degeneration Retinal Degeneration Retinal Diseases Skin and Connective Tissue Diseases

Age range

18 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Fondation ophtalmologique Adolphe de Rothschild

Paris, 75019, France

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Systemic lupus erythematosus
Case patients : with "pseudo-drusen-like" deposit
Control patients : without "pseudo-drusen-like" deposit

Exclusion criteria

Patient under a measure of legal protection

Treatment and study plan

Blood test

Procedure

Blood test for complement factors and genetic polymorphisms of AMD analysis

Primary outcomes

Comparison of AMD genetic polymorphisms between case and control patients

Time frame: Baseline
Comparison of complement factors between case and control patients

Time frame: Baseline

Sponsors and collaborators

Lead sponsor

Fondation Ophtalmologique Adolphe de Rothschild

Network

Registry information

Official study title

Comparison of Complement Factors and Genetic Polymorphisms of AMD Between Patients With Systemic Lupus Erythematosus (SLE) With and Without Retinal "Pseudo-drusen-like" Deposits: Case-control Study (PLAMD)

Acronym: PL-AMD

Important dates

Study start: 2018
Primary completion: 2021
Study completion: 2021
First posted: Apr 20, 2018
Registry last updated: May 24, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed