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NCT Number: NCT07429448

Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Preemptive Analgesia in Patients Undergoing Open Appendectomy

To compare the clinical outcomes of intraperitoneal bupivacaine instillation vs placebo as preemptive analgesia in patients undergoing open appendectomy

Recruiting

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Key information

Conditions

Appendectomy Agnosia Nervous System Diseases Neurobehavioral Manifestations Neurologic Manifestations Pathological Conditions, Signs and Symptoms Perceptual Disorders Signs and Symptoms

Age range

20 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 1

Primary location

Services Institute of Medical Sciences/ Services Hospital Lahore

Lahore, Punjab Province, 54000, Pakistan

Location status: Recruiting

Location contact

Prof Javaid Ur Rehman Ashraf, MBBS, FCPS

CONTACT

[email protected]

+923334233682

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients presenting to the emergency department undergoing open appendectomy.

Exclusion criteria

  • Patients undergoing interval appendectomy or having perforated appendix as evident by examination (abdominal tenderness/ fever) and USG findings (presence of abscess, fluid collection, or free air).
  • Uncontrolled medical disease (DM: BSL >200mg/dl, HTN: BP >140/90)
  • History of chronic kidney or liver disease/ psychiatric illness/ Active peptic ulcer disease (as determined on history and medical records)
  • Alcoholics
  • History of chronic pain or patients on analgesic medications
  • Pregnant females
  • History of allergy to bupivacaine/ ketorolac as determined on history
  • Children, Adolescents and patients with mental illness.

Treatment and study plan

Bupivacain

Drug

Bupivacaine with 0.25% of concentration at the end of the operation intraperitoneally.

Normal Saline

Other

10ml of Normal Saline at the end of the operation intraperitoneally.

Primary outcomes

  1. Post operative pain

    Time frame: 24 hours

    Intensity of post operative pain by using visual analogue score and frequency of postoperative rescue analgesics if required after instillation of bupivacaine and placebo in both groups. Both outcomes will be noted at different intervals i.e. 2, 6, 12 and 24 hours postoperatively for comparison as mentioned.

Study contacts

Contact information is provided by the study sponsor or research team.

Dr Sardar Umar Rehman, MBBS

CONTACT

[email protected]

+923319326657

Sponsors and collaborators

Lead sponsor

Sardar Umer Rehman

Other Gov

Collaborators

  • Services Institute of Medical Sciences, Pakistan

Registry information

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Feb 24, 2026
Registry last updated
Feb 24, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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