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OpenTrials
Completed

NCT Number: NCT00352937

Comparison of Cardiac Computed Tomography for the Detection of Coronary Artery Disease With Nuclear Stress Test

To compare the efficacy of 16-row multi-detector CT (MDCT) with standard myocardial perfusion imaging in detecting coronary artery disease (CAD) in patients without a previously established diagnosis of CAD.

Completed

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Key information

Conditions

Coronary Arteriosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Coronary Artery Disease Coronary Disease Heart Diseases Myocardial Ischemia Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Providence Veterans Affairs Medical Center

Providence, Rhode Island, 02908, United States

About this study

Nuclear stress testing is currently the established non-invasive modality in detecting flow-obstructing coronary artery disease (CAD).

Recently, multi-detector CT (MDCT) has emerged as a new modality that offers a non-invasive means to directly visualize coronary anatomy and any CAD. Studies have shown that MDCT has excellent sensitivity and a high negative predictive value in detecting significant CAD.

The purpose of this study is to compare MDCT with nuclear stress testing for detecting CAD in previously undiagnosed patients.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Referred for a clinical indicated stress SPECT MPI
  • Adequate IV access in both arms

Exclusion criteria

  • History of coronary angioplasty or stent placement
  • History of coronary bypass surgery
  • Angiographic history of flow-limiting CAD
  • Documented history of elevated cardiac markers
  • Documented history of injury or infarct on ECG
  • Absence of sinus rhythm
  • Current history of renal insufficiency
  • Known allergy to contrast dye
  • Pregnant

Treatment and study plan

Primary outcomes

  1. Calcium score

    Time frame: 1 year

Sponsors and collaborators

Lead sponsor

Providence VA Medical Center

Fed

Registry information

Important dates

Study start
2006
Primary completion
2009
Study completion
2009
First posted
Jul 17, 2006
Registry last updated
May 15, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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