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Completed

NCT Number: NCT04638504

Comparison of Brachial Artery Dilatation, Uterine Artery Doppler, Umbilical Artery Doppler and 1st-trimester Visceral Adipose Tissue Measurement in Obese and Normal Pregnant Women

Brachial artery flow-mediated in obese and normal-weight pregnant women dilation of uterine artery doppler and umbilical artery doppler results comparison of

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Key information

Conditions

Obese Body Weight Cardiovascular Diseases Nutrition Disorders Nutritional and Metabolic Diseases Obesity Obesity, Abdominal Overnutrition Overweight Pathological Conditions, Signs and Symptoms Pregnancy Related Signs and Symptoms Vascular Diseases Visceral Obesity

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Diyarbakır Women's and Children's Hospital

Diyarbakır, 21100, Turkey (Türkiye)

About this study

The systemic inflammatory effect caused by obesity and vascular disorder It has been reported that it creates studies. Healthy Vascular Endothelial structure increases vascular tone by regulating nitric oxide (NO) release. Reduced nitric oxide production, reducing flexibility It has a facilitating effect on hypertensive diseases and other obstetric diseases.

Endothelial function, which is a non-invasive, easily applicable, and reproducible method It can be detected by endothelium-dependent vasodilation. A good indicator of endothelial function in studies in which the brachial artery flow-mediated dilation (FMD) shown. Brachial artery blood pressure cuff at forearm level in normal healthy people with compression for 3-5 minutes 50 mmHg above systolic pressure, 60-120 seconds after loosening the cuff When measured later, individuals with healthy endovascular function and the brachial artery are also reactive hyperemia, and a 10% dilatation is expected. Many obstetric effects such as obesity preeclampsia, preterm labor, gestational diabetes, preterm labor Although it was found to be related to pathology, the relationship between them could not be determined exactly.

Our study aimed to increase brachial artery dilatation in obese and normal pregnant women.

By comparing, determine the level of nitric oxide and endovascular function. Also uterine Vascular structures of obesity by comparing vascular structures with artery and umbilical uterine dops examine the effect on

Pregnant women between the ages of 18-40 who apply to the Diseases and Obstetrics outpatient clinic will be taken. 24-28. Brachial artery dilatation, uterine, and umbilical artery doppler between 11-14, 37-40w weeks between gestational weeks, and visceral adipose tissue measurement at first trimester will be examined.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • obese and normal pregnant
  • 11-14 weeks
  • 24-28 weeks
  • 37-40 weeks

Exclusion criteria

  • smoking
  • chronic vascular disease
  • Diabetes mellitus
  • Over 40 years old

Treatment and study plan

Ultrasonography

Other

vascular and adipose tissue measurement by ultrasonography

Primary outcomes

  1. To define the relationship between obesity and endovascular dysfunction by brachial artery dilatation method.

    Time frame: 3 month

    To examine the possible effects of obesity on the endovascular system with the brachial artery dilation method.

  2. Measurement of uterine artery doppler in obese and normal pregnant women

    Time frame: 3 month

    To determine whether obesity has an effect on uterine artery resistance.

  3. Measurement of obese and normal pregnant umbilical artery doppler

    Time frame: 3 month

    trying to understand whether obesity has fetal effects by examining umbilical artery doppler in obese pregnants and normal pregnants,

  4. First trimester visceral adipose tissue and brachial artery measurement

    Time frame: 3 month

    By measuring the amount of visceral tissue in the first trimester obese and normal pregnant women with Armellini method; Investigation of its effects on endovascular dysfunction through brachial artery dilatation

Sponsors and collaborators

Lead sponsor

Diyarbakir Women's and Children's Diseases Hospital

Other

Registry information

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Nov 20, 2020
Registry last updated
Mar 2, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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