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NCT Number: NCT06946043

Comparison of Anterior Chamber Depth in High Myopes

This study aims to compare the accuracy and reliability of anterior chamber depth (ACD) measurements obtained using three imaging modalities: anterior segment optical coherence tomography (A-S OCT), ultrasound biomicroscopy (UBM), and the Pentacam Scheimpflug imaging system. The research focuses on high myopic patients and evaluates the consistency and correlation of these measurements with the degree of myopia.

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Key information

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

The research is a cross-sectional, prospective, observational cohort study conducted in ophthalmological settings at Assiut University Hospital, Elforsan Center, and Tyba Center. It investigates the anterior chamber depth (ACD) in high myopes using three advanced diagnostic imaging tools:

Anterior Segment Optical Coherence Tomography (A-S OCT): A non-invasive imaging technique for high-resolution cross-sectional imaging of the anterior segment.

Ultrasound Biomicroscopy (UBM): An imaging method that uses high-frequency ultrasound to visualize anterior segment structures.

Pentacam HR (Scheimpflug Imaging System): A device that provides three-dimensional imaging of the anterior chamber.

The primary objective is to determine the mean differences in ACD measurements among these devices. Secondary objectives include assessing the correlation between ACD measurements and the degree of myopia, as well as evaluating the repeatability of measurements for each device.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 years or older
  • High myopes with axial length >26mm or , and refractive error > -6 ,00 D
  • Ability to fixate for OCT and Pentacam imaging

Exclusion criteria

  • History of ocular surgery or trauma
  • Presence of corneal pathology
  • Active ocular inflammation
  • Inability to fixate for imaging procedure

Treatment and study plan

Primary outcomes

  1. Mean difference in ACD measurements between A-S OCT, UBM, and Pentacam.

    Time frame: During the procedure

    The study will calculate and compare the average differences in anterior chamber depth measurements obtained by each device to assess their accuracy and reliability.

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

Comparison of Anterior Chamber Depth Measured by Anterior Segment Optical Coherence Tomography , Ultrasound and Pentacam in High Myopes

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Apr 27, 2025
Registry last updated
Apr 27, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.