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NCT Number: NCT05632107

Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor

A quantitative neuromuscular monitoring device is desirable to titrate the depth of neuromuscular block (NMB) during a procedure, and to prevent residual effects after removal of the endotracheal tube. Unfortunately, the most widely used monitoring technique acceleromyography (AMG) typically implies a series of cumbersome installation and calibration procedures that frequently precludes correct use of these devices in clinical practice. Electromyography (EMG) has recently attracted a lot of attention as an alternative strategy to compensate for the deficiency of AMG-based neuromuscular monitors. Nowadays, a new technology that allows for the simultaneous acquisition of EMG and AMG signals is commercially available. Although its reliability has been rapidly accepted in Physical Medicine and Rehabilitation, the use of the technique in neuromuscular monitoring has never been reported. The aim of the present study is to assess the validity of the new device for estimating the neuromuscular block by comparing with TOF Watch®-SX, which is the most widely accepted AMG-based neuromuscular monitor that has been practiced in the clinical arena for decades.

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Key information

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Anaesthesiology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age less than 18 yr
  • American Society of Anesthesiologists Physical Status I to III
  • Elective surgery requiring muscle relaxation
  • Patients participated voluntarily and signed informed consent

Exclusion criteria

  • Patients with known neuromuscular disorder
  • Stroke
  • Patients with a history of allergic reaction toneuromuscular blocking agents
  • Use of medications that might interfere with neuromuscular transmission
  • Any previous injury to the examined arm that might influence nerve conduction parameters
  • Pacemaker

Treatment and study plan

TOF-Watch®;DELSYS® Wireless surface EMG

Device

TOF-Watch® is the most widely accepted AMG-based neuromuscular monitor; and DELSYS® Wireless surface EMG is a new technology that allows for the simultaneous acquisition of EMG and AMG signals in a wireless manner.

Primary outcomes

  1. Assessing the correlation between the train-of-four (TOF) obtained from the 2 devices

    Time frame: Perioperative data

  2. Assessing the correlation between the posttetanic count (PTC) obtained from the 2 devices

    Time frame: Perioperative data

Secondary outcomes

  1. Screening for eligible individual signal sources from the multiplex information of the new technology for improving neuromuscular monitoring

    Time frame: Perioperative data

Study contacts

Contact information is provided by the study sponsor or research team.

Hua Zheng, Dr.

CONTACT

[email protected]

0086-27-83663173

Sponsors and collaborators

Lead sponsor

Huazhong University of Science and Technology

Other

Registry information

Official study title

Comparison of an Acceleromyography- and Electromyography-based Neuromuscular Monitor With TOF-Watch ® Monitor:a Pilot Study

Important dates

Study start
2023
Primary completion
2026
Study completion
2027
First posted
Nov 30, 2022
Registry last updated
Apr 3, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

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This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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