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OpenTrials
Completed

NCT Number: NCT07246174

Comparison of AH Plus and WellRootST Root Canal Sealers in Terms of Postoperative Pain: One-Month Follow-up

The objective of this research was to identify which of the root canal sealers, AH Plus or WellRootST, yielded more effective outcomes regarding postoperative pain when applied to teeth diagnosed with apical periodontitis.

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Key information

Conditions

Root Canal Treatment Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Istanbul Medipol University

Istanbul, Turkey (Türkiye)

About this study

A prospective cohort study was conducted at a single center, involving 120 patients diagnosed with chronic apical periodontitis (AP) admitted for endodontic treatment. Patients were categorized into two groups based on the type of root canal sealer used. Sixty patients treated with AH Plus sealer constituted Group 1, while sixty patients treated with WellRootST sealer comprised Group 2. Data collected for all participants included age, gender, findings from oral and dental examinations, tooth type, tooth number, duration of root canal treatment, and Visual Analog Scale (VAS) results recorded preoperatively, as well as at 24 hours, 48 hours, 72 hours, 1 week, and 1 month postoperatively.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

The inclusion criteria for this study were as follows:

  • Participants had to be at least 18 years old
  • One mature tooth showing signs or symptoms that required primary root canal treatment.
  • Participants needed to be in good general health
  • classified as ASA I or II, and able to follow the follow-up schedule.

Exclusion criteria

criteria for this study were as follows:

  • Included teeth with internal or external root resorption,
  • Signs of perforation
  • The need for post-core application, or previous restoration with fixed prosthetic appliances, such as crowns or bridges

Treatment and study plan

AH-Plus Epoxy Resin Sealer

Procedure

AhPlus sealer was used for group 1

bioceramic sealer

Procedure

WellRootSt wa used for group 2

Primary outcomes

  1. postoperative pain evaluation by VAS scale

    Time frame: Baseline, 24 hour postoperatively, 48hour postoperatively, 72 hour postoperatively, Day 3 and Day 7

    Study groups were compared in terms of VAS scores at the preoperative period and postoperative 24 hours, 48 hours, 72 hours, 1 week, and 1 month

Sponsors and collaborators

Lead sponsor

Medipol University

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Nov 24, 2025
Registry last updated
Nov 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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