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OpenTrials
Completed

NCT Number: NCT02484157

Comparison of ACT Between Hemochron Jr and ACT Plus

This study aimed to compare 2 activated clotting time analysers (Hemochron Jr vs. ACT Plus).

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Key information

Conditions

Cardiac Disease Cardiovascular Diseases Heart Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hallym University Sacred Heart Hospital

Anyang-si, Gyeonggi-do, KS009, South Korea

About this study

Measurement of activated clotting time (ACT) is a standard method for anticoagulation monitoring. Especially in cardiac surgery, heparin is usually used as anticoagulant and protamine is used to reverse anticoagulation effect at the end of surgery. ACT method defines the time until a clot is formed in a test tube after triggering of internal pathway coagulation using blood activating agents (eg. kaolin).

Acute normovolemic hemodilution (ANH) consists of withdrawing patient's blood volume early in the operative period and concurrent infusion of crystalloid or colloid to maintain intravascular volume, and is used in cardiac surgery. ANH is known to affect hemostasis in some studies.

Assuming that accurate monitoring of coagulation therapy is important to prevent both thrombotic and hemorrhagic complications, we compared ACT results from 2 analysers (Hemochron Jr and ACT Plus) in patients undergoing cardiac surgery using ANH.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who underwent cardiac surgery with heparin administration.

Exclusion criteria

  • Preoperative hemoglobin under 11g/dL
  • Weight under 40kg
  • Preoperative coagulopathy

Treatment and study plan

Hemochron

Device

Activated coagulation time was checked serially by Hemochron Jr.

ACT Plus

Device

Activated coagulation time was checked serially by ACT Plus.

Primary outcomes

  1. Comparison of activated coagulation time between Hemochron Jr and ACT Plus

    Time frame: During cardiac surgeris (within 8 hours)

Sponsors and collaborators

Lead sponsor

Hallym University Medical Center

Other

Registry information

Official study title

Comparison of Activated Coagulation Time Between Hemochron Jr and ACT Plus During Cardiac Surgery for Patient Using Acute Normovolemic Hemodilution

Important dates

Study start
2012
Primary completion
2013
Study completion
2014
First posted
Jun 29, 2015
Registry last updated
Jun 29, 2015

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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