Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation

Vascular inflammation is a key factor in both the pathogenesis and outcome of atherosclerosis. 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET) is a promising tool for identifying and quantifying vascular inflammation within atherosclerotic plaques.cardiac multidetector-row CT can provide measurements of coronary artery calcium (CAC), the degree of stenosis, and the characteristics of plaque including its potential vulnerability. Therefore, the purpose of the investigators study is to compare the usefulness of 18 FDG-PET and MDCT in assessing the vascular inflammatory status and vulnerability.

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Key information

Conditions

Atherosclerosis Arterial Occlusive Diseases Arteriosclerosis Cardiovascular Diseases Vascular Diseases

Age range

20 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Hye Jin Yoo

Seoul, South Korea

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Healthy patients for visiting routine medical check in our clinic

Exclusion criteria

History of cardiovascular disease (myocardial infarction, unstable angina, stroke, or cardiovascular revascularization)
Diabetes
Stage 2 hypertension (resting blood pressure, ≥ 160/100 mmHg)
Malignancy
Severe renal or hepatic disease
Subjects taking medications that might affect inflammation such as NSIAD and statin

Treatment and study plan

Cross section study

Other

This is not intervention study. The purpose of the study is to examine the relationship of vascular inflammation assessed by 18FDG-PET and MDCT at the cross section setting

Primary outcomes

Correlation between vascular inflammatory status measured by 18FDG PET and MDCT

Time frame: 20weeks

Secondary outcomes

Comparison the correlation with inflammatory marker and vascular inflammatory status assessed by 18FDG PET and MDCT

Time frame: 20 weeks

Sponsors and collaborators

Lead sponsor

Korea University

Other

Registry information

Official study title

Comparison of 18F-fluorodeoxyglucose Positron Emission Tomography and Coronary Computed Tomography in Assessing Vascular Inflammation in Healthy Population

Important dates

Study start: 2010
Primary completion: 2011
Study completion: 2011
First posted: Apr 9, 2010
Registry last updated: Mar 14, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed