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NCT Number: NCT07648810

Comparison Immune Response in Paravertebral and Erector Spinal Plane Block in Breast Cancer Patients

The goal of this clinical trial is to find the difference in immune response between two types of regional anesthesia in female patients suffering from breast cancer.

The main question it aims to answer is there a difference in the immune response between paravertebral block and erector spinal plane block.

Hypothresis of the study is that paravertebral block with propofol induces less immune response in surgical treatment of breast cancer patients than erector spinal plane block.

Participants will be asked to sign the informant consent. They will be given either paravertebral block or erector spinae plane block with general anesthesia using propofol. Their venous blood will be taken 1 hour prior surgery and 24 and 48 hours after surgery.

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Key information

Conditions

Breast Cancer - Female

Age range

18 year–70 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I and ASA II status, normal BMI

Exclusion criteria

  • ASA III and ASA IV status, coagulopathy, chronic opioid use, diabetes, local infection of the skin

Treatment and study plan

Regional Anesthetic Injection

Procedure

Draw of venous blood and application of paravertebral and erector spinae plane block

Blood draw for the laboratory assessment

Procedure

Draw of venous blood 24 hours after surgery

Primary outcomes

  1. Immune response in two different regional anesthesia techniques

    Time frame: From enrollment to 30 days post surgery

Study contacts

Contact information is provided by the study sponsor or research team.

Jan Maroević, medical doctor

CONTACT

[email protected]

+385981859039

Sponsors and collaborators

Lead sponsor

Clinical Hospital Center Rijeka

Other

Registry information

Official study title

Immunologic Response in Breast Cancer Before and After Application of Paravertebral and Erector Spinae Plane Block

Acronym: IRPVBESP

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Jun 15, 2026
Registry last updated
Jun 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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