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NCT Number: NCT07423676

Comparison Between Two Drugs in Sedation of Upper GI Endoscopy

The goal of this clinical trial is to compare time of sedation between two drugs administered to patients undergoing upper gastrointestinal endoscopy Primary outcome : Time of sedation : is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs

Secondary outcome :

* Recovery time :is the time to reach score 2 of modified Ramsay sedation score starting from injecting bolus dose of study drugs . * Hemodynamics (MAP,HR) & oxygen saturation * Drug side effects (nausea,vomitting,agitation) * Endoscopist satisfaction

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Key information

Conditions

Sedation During GI Endoscopy

Age range

21 year–60 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient acceptance
  • Adults aged 21-60 years.
  • Both sexes
  • BMI<35 kg/m2
  • ASA physical status :I& II
  • Patients Undergoing Gastrointestinal endoscopy
  • Duration <30mintues

Exclusion criteria

  • • Known allergy to any of the study drugs
  • Unstable Cardiovascular disease
  • Moderate to severe respiratory diseases

Treatment and study plan

Primary outcomes

  1. Comparison between time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy

    Time frame: Baseline

    Time of sedation :is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs

  2. Comparison time of sedation between ketamine Dexametomidine and propofol midazolam in sedation of GI endoscopy

    Time frame: Baseline

    Time of sedation:is the time to reach sedation score of 5 according to modified Ramsay sedation score starting from the time of injecting bolts dose of study drugs

  3. Comparison of time of sedation between ketamine Dexametomidine g

    Time frame: Basline

    • Time of sedation :is the time to reach score 5 of modified Ramsay sedation score starting from injecting bolus dose of study drugs .

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmed Esam Hamad, Register

CONTACT

[email protected]

+201095529439

Sponsors and collaborators

Lead sponsor

Zagazig University

Other Gov

Registry information

Official study title

Ketamine - Dexmedetomidine(Ketodex) Versus Propofol -Midazolam for Sedation in Patients Undergoing Upper Gastrointestinal Endoscopy

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Feb 20, 2026
Registry last updated
Feb 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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