Skip to main content
OpenTrials
Recruiting

NCT Number: NCT07482709

Comparison Between Tranversus Abdominis Plane (TAP) Block With Only Bupivacaine and TAP Block With Bupivacaine Plus Ketamine in Reducing Postoperative Pain After Total Abdominal Hystrectomy

The goal of this study is to know how effectively TAP block can reduce postoperative pain in total abdominal hystrectomy patients when given ketamine in addition to bupivacaine in TAP block and to compare it with the conventional TAP block with bupivacaine only. The main question it aims to answer is:

Does intervention with ketamine in TAP block lowers the postoperative pain measured via visual analog scale and decreases the need for rescue analgesia?

Patients will be assessed for pain in PACU( post anesthesia care unit), 6 hours, 12 hours and 24 hours postoperatively. Time of rescue analgesia will also be noted if given.

Recruiting

Interested in participating?

Request Info

Key information

Conditions

Post Operative Pain in Total Abdominal Hystrectomy Neurologic Manifestations Pain Pain, Postoperative Pathologic Processes Pathological Conditions, Signs and Symptoms Postoperative Complications Signs and Symptoms

Age range

25 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Phase 1 / Phase 2

Primary location

gynae operation theatre at Liaquat National Hospital

Karachi, Sindh, 74800, Pakistan

Location status: Recruiting

Location contact

gynae theatre

CONTACT

[email protected]

(021)111-456-456

About this study

This is a prospective, randomized, double blind control trial.Patients will be randomly divided into 2 groups; group A and group B with 15 patients in each group. Group A will recive TAP block with 20ml solution of 0.25% bupivacaine on each side of abdomen while group B will recieve 50mg ketamine in addtion to 20ml of 0.25% bupivacaine.The drugs will be prepared by the second anesthesiologist who will not be part of data collection and analysis.Post operative pain will be assessed using VAS score in PACU, after 6 , 12 and 24hours post total abdominal hystrectomy. Inj. tramadol 50mg will be used as rescue analgesia.In addition to inj. pracetamol 1g 8 hourly and inj. ketorolac 30mg 12 hourly, time for administration of rescue analgesia will be noted.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged between 25 to 60 years.
  • ASA grade I & II.
  • Undergoing total abdominal hysterectomy.

Exclusion criteria

  • BMI >35kg/m2.
  • Patient refusal for participation.
  • Patients with coagulation disorders.
  • Patents with history of allergy and hypersensitivity to local anesthetic.
  • Patient having infection at the injection site.
  • Alcohol or drug abuse.
  • Cognitive or mental disorder.

Treatment and study plan

bupivicaine 0.25%

Drug

20ml of 0.25% bupivacaine inTAP block

bupivicaine 0.25% + ketamine

Drug

20ml of 0.25% of bupivacaine with 50mg ketamine in TAP block

Primary outcomes

  1. VAS score

    Time frame: At PACU(5 mins after shifting to PACU), 6,12 and 24 hours post-operatively

    VAS (visual analog scale ) score noted VAS of <2 = no pain VAS of 2-4 = mild pain VAS of 5-6 = moderate pain VAS of >6 = severe pain

  2. Time of receiving first rescue analgesia

    Time frame: within first 24 hours postoperatively

    time for additional requirment of inj. tramadol 50mg for post operative pain relief

Sponsors and collaborators

Lead sponsor

Liaquat National Hospital & Medical College

Other

Registry information

Official study title

Transversus Abdominis Plane Block : A Comparative Study Between Bupivacaine vs Bupivacaine With Ketamine in Total Abdominal Hystrectomy

Acronym: TAP-BvsBK-TAH

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 19, 2026
Registry last updated
Mar 25, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.