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Completed

NCT Number: NCT02561390

Comparison Between spIgE and Skin Prick Test of Local and Imported Aeroallergens

The prevalence of Allergic rhinitis(AR) and asthma was increased world wide. In 1998, ISAAC found that prevalence of AR and asthma inThailand was in moderately high group.

Tests for immediated reaction SPT and spIgE, were used for evaluated sensitization of allergen in patient. They guided the investigators for proper management as well as patient education. Clinician will use the result for choose allergen in case that might need immunotherapy.

SPT is safe and more economic for patient. Specific IgE has an advantage in patient who cannot withhold antihistamine prior SPT. In United state had a trial of result between SPT and spIgE for cockroach, cat, house dust mite and mold. It showed the correlation between two tests. In Thailand, the investigators haven't had data about it yet.

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Key information

Conditions

Immediate Hypersensitivity Hypersensitivity Hypersensitivity, Immediate Immune System Diseases

Age range

10 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Medicine Siriraj Hospital

Bangkoknoi, Bangkok, 10700, Thailand

About this study

SPT and specific IgE for allergens is necessary for allergen avoidance and specific immunotherapy. To have local allergen extracts will help the patients to easier get the appropriate management

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patient with controlled Asthma and/or AR (mild to moderate severity) who were diagnosed in Allergy clinic and ENT clinic, Siriraj hospital
  • SPT positve one of American Cockroach, House dust mite, cat, dog and mold.
  • Patient were consented to trial.

Exclusion criteria

  • Chronic disease such as heart disease, liver, renal and severe sepsis
  • History of anaphylaxis
  • Skin rash
  • Pregnancy

Treatment and study plan

skin prick test

Procedure

skin prick test to American cockroach, dog, cat, dust mite and mold allergen extracts are performed

specific IgE measurement

Other

measure specific IgE of American cockroach, dog, cat, dust mite and mold

Primary outcomes

  1. mean wheal diameter of SPT of local and imported allergen extracts and specific IgE levels

    Time frame: 18 months

    measure and compare SPT result of local and imported allergen extracts

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

In-vivo Potency Evaluation of American Cockroach, Dog, Cat, Dust Mites and Mold Allergen Extracts Produced by Siriraj Hospital Comparing With Imported Extracts by Using Skin Prick Test.

Important dates

Study start
2013
Primary completion
2014
Study completion
2014
First posted
Sep 28, 2015
Registry last updated
May 4, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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