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NCT Number: NCT07512219

Comparison Between Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine

Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study

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Key information

Conditions

Chronic Migraine, Headache Headache Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient with Diagnosis of chronic migraine for > 3 months.
  • migraine days ≥ 15 days/month.
  • Failure or inadequate response to standard medical treatment.

Exclusion criteria

  • Secondary headache disorders.
  • Coagulopathy or anticoagulant therapy.
  • Infection at injection site.
  • History of cervical spine surgery.
  • Pregnancy or breastfeeding.
  • Previous PRF or occipital nerve surgery within last 3 months

Treatment and study plan

Greater occiptal nerve block

Drug

Injection Procedure:

  • Local skin infiltration with 1-2 mL of 1% lidocaine at puncture site.
  • GON block using 3-5 mL of local anesthetic, optionally combined with 20-40 mg triamcinolone ( Bilaterally )
  • Needle placement confirmed by ultrasound visualization of the nerve and spread of injectate.
  • Observe patient for 15-20 minutes post-injection for immediate adverse events.

Other names: GONB

Pulsed Radiofrequency

Device
  • Introduce RF cannula adjacent to GON under ultrasound guidance.
  • Confirm sensory stimulation: paresthesia at occipital scalp at <0.5 V.
  • PRF settings:
  • Temperature: ≤42°C
  • Pulse duration: 20 ms
  • Frequency: 2 Hz
  • Duration: 120 seconds per cycle, 2 cycles per side
  • Continuous monitoring of patient comfort and vital signs.

Other names: PRF

Primary outcomes

  1. The change in the VAS score of Pain over period of follow up

    Time frame: 6 months

    after do GONB and Pulsed radio frequency we assess improvement of Episodic Pain over period of Follow up

Study contacts

Contact information is provided by the study sponsor or research team.

shehab Mahmoud mohamed, assisstant lecturer

CONTACT

[email protected]

0201090442332

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Comparative Study of Greater Occipital Nerve Block and Pulsed Radiofrequency in the Management of Chronic Migraine : Clinical Outcomes and Neurophysiological Correlates A Prospective Randomized Study

Important dates

Study start
2026
Primary completion
2026
Study completion
2027
First posted
Apr 6, 2026
Registry last updated
Apr 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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