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Completed

NCT Number: NCT00634491

Comparison Between Effect of Acetazolamide and NaHco3 in Prevention of Contrast Nephropathy

The purpose of this study is whether Acetazolamide is effective in prevention of contrast nephropathy

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Key information

Conditions

Contrast Induced Nephropathy

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Fars Heart Foundation , Kowsar hospital

Shiraz, Iran

About this study

Contrast induced nephropathy is one of common causes of acute renal failure many preventive protocol existed . 240 patient that underwent coronary angiography randomly divided in three groups.Group 1,2,3 will receive Bicarbonate ,Acetazolamide+Normal salin and Normal salin respectively.We compare prevalence of contrast nephropathy in each group.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patient that underwent coronary angiography

Exclusion criteria

  • serum Cr. more than 3 mg/dl
  • electrolyte and acid-base imbalance
  • pulmonary edema
  • allergy to Acetazolamide

Treatment and study plan

Sodium bicarbonate

Drug

150 meq/l Sodium bicarbonate 3cc/kg/hr before and 1cc/kg/hr after angiography

Other names: no other name

Acetazolamide

Drug

Acetazolamide 250 mg+ 1 cc/kg/hr normal salin before and after angiography

Other names: Diamox

normal salin

Drug

1 cc/kg/hr 6 hour before and after angiography

Other names: no other name

Primary outcomes

  1. Increased base line creatinine at least 25%

    Time frame: 24 hr later

Sponsors and collaborators

Lead sponsor

Shiraz University of Medical Sciences

Other

Collaborators

  • Fars Heart Foundation

Registry information

Official study title

Effect of Acetazolamide in Prevention of Contrast Nephropathy

Important dates

Study start
2007
Primary completion
2008
Study completion
2008
First posted
Mar 13, 2008
Registry last updated
Mar 13, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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