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Completed

NCT Number: NCT05279482

Comparison Between Different Doses of Steroids in COVID-19 Patients

aim of this study is to compare between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate, percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.

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Key information

Conditions

Critical Illness Disease Attributes Infections Lung Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Pneumonia Pneumonia, Viral Respiratory Tract Diseases Respiratory Tract Infections Virus Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Ain shams university hospitals, Cairo, Egypt

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About this study

Retrospective study for comparison between standard dose methyl prednisolone and mega dose methyl prednisolone as regards outcome reflected by mortality rate ,percentage of mechanically ventilated patients and icu length of stay of covid 19 patients admitted in intensive care unit.

Previous studies suggested that cytokine release syndrome could be involved in the pathophysiology of critical SARS.COV.2 resulting in death so early suppression of cytokine storm may be lifesaving in critical patients.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All icu admitted covid 19 patients with positive PCR, diagnosed by CT chest and needing oxygen therapy

Exclusion criteria

  • Not requiring oxygen therapy
  • Negative PCR
  • Uncontrolled blood sugar or DKA
  • Patients on long term steroids therapy

Treatment and study plan

observation for outcome of methylprednisolone dose

Other

no intervention as it is retrospective study for outcome

Primary outcomes

  1. 28 days mortality rate

    Time frame: 1 month

    observation for mortality rate in both groups

Secondary outcomes

  1. mechanical ventilation and icu length of stay

    Time frame: up to 3 months

    observation for percentage of mechanically ventilated patients and length of stay

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

Comparison Between Standard Dose Methyl Prednisolone and Megadose Methyl Prednisolone as Regards Outcome in SARS.COV.2 Patients in Intensive Care Unit : Retrospective Study

Acronym: COVID-19

Important dates

Study start
2022
Primary completion
2022
Study completion
2022
First posted
Mar 15, 2022
Registry last updated
Mar 15, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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