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Completed

NCT Number: NCT05058794

Comparison Among the Effects of Blood Flow Restriction Training and Conventional Exercise in Knee Osteoarthritis.

The main objective of the study is to compare the effects of Blood flow Restriction training vs. traditional exercises on knee pain , knee functional disability and on quadriceps strength in patient with knee osteoarthritis.

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Key information

Conditions

Osteoarthritis, Knee Arthritis Hypertrophy Joint Diseases Musculoskeletal Diseases Osteoarthritis Pathological Conditions, Anatomical Pathological Conditions, Signs and Symptoms Rheumatic Diseases

Age range

40 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Gulberg Medical Complex, Islamabad, Federal, Pakistan

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About this study

Osteoarthritis is a degenerative disease affecting the most commonly weight bearing joint.The common form of arthritis is osteoarthritis (OA) causing structural changes in the joint. Age is a common factor affecting the strength and muscle mass.Worldwide there is a drastic increase of osteoarthritis in the older population. In the past 20 years the prevalence of knee pain increased and reached up to 50% in the older population. The most common OA affecting lower extremity is in the knee Joint.Majority of the people affected by knee OA are the older population. Knee Joints being the most weight bearing joint affected in OA causing pain , limiting function and mobility.Mobility and function may be affected in osteoarthritic population usually experience pain and stiffness.

The main objective of this study is to compare the Effects of blood Flow restriction training vs conventional treatment exercises on knee pain, functional disability and quadriceps strengthening.

The main purpose of this study is to improve the muscular strength of lower limbs which are being affected in a disease osteoarthritis in the adult population.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pain : Subjects having unilateral or bilateral pain
  • Pain type : subjects having chronic pain
  • Includes diagnosed cases of knee osteoarthritis
  • grades 2-3 according to the Kellgren and Lawrence method of grading
  • Includes knee osteoarthritis patients with lateral tracking of patella which will assessed through Q angle test

Exclusion criteria

  • Any other orthopaedic or neurological condition of hip and knee
  • Sign and symptoms of lower motor neuron disease
  • Current use of medication
  • Radiculopathy
  • Fracture
  • Malignancy
  • Thromboembolism
  • Decreased range of motion

Treatment and study plan

Blood flow Restriction/Resistance Training

Other

During each exercise, only blood flow in the involved leg was restricted using an aneroid sphygmomanometer. Prior to exercise the cuff was placed on the most proximal portion of the limb and limb occlusion pressure (LOP) was calculated in the body position that the Blood flow Restriction (BFR) stimulus would be applied. Blood Flow Restriction BFR pressure was set at 50% occlusion. Resistance applied for 1 minute (60 sec) with 30 % load of 1 repetition maximum. Subjects will receive treatment bilaterally. Participants will perform exercises 2 sets with 15 repetitions through 0 to 90 degrees.

Conventional therapy group

Other

Resistance applied for 1 minute (60 sec) with 30 % load of 1 repetition maximum. Subjects will receive treatment bilaterally.participants will perform 2 sets with 15 repetitions in (0 to 90 degree.)

Primary outcomes

  1. Muscle strength

    Time frame: 6 weeks

    Measurement of Quadriceps strength with portable weight machine.

  2. Thigh Girth

    Time frame: 6 weeks

    Participants will be supine lying and knee in extension, standing or knee at 90 degree. Proximal to the patellar pole superiorly one measurement with a non-elastic tape at the inguinal fold, then mark the mid-point at the mid-thigh level measuring in centimeters/inches.

  3. Numeric Pain Rating Scale ( NPRS)

    Time frame: 6 weeks

    Patient will be asked if there is any pain in knee from the scale of 0 to 10.

  4. Q angle Measurement

    Time frame: 6 weeks

    Subject will be in supine position with knee extension and quadriceps are relaxed, examiner will measure the q angle with flexible inch tape and goniometer. The Q- angle is measured by extending a line through the center of the patella to the anterior superior iliac spine and another line from the tibial tubercle through the center of the patella.

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Effects of Blood Flow Restriction Training vs Traditional Exercise in Patients With Knee Osteoarthritis.

Important dates

Study start
2021
Primary completion
2022
Study completion
2022
First posted
Sep 28, 2021
Registry last updated
Mar 23, 2022

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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