Comparing Two Weight Loss Programs for the Prevention of Kidney Cancer Progression Among Patients With Small Renal Masses on Active Surveillance

PRIMARY OBJECTIVES:

I. Adapt two evidence-based behavioral weight loss intervention programs (IF and CER) with a goal to cause weight loss in SRM patients on AS.

II. Determine the feasibility of the two intervention programs (IF and CER).

SECONDARY OBJECTIVE:

I. Measure and explore preliminary effect sizes of IF vs. CER on body weight, diet, body composition, tumor growth, and rates of clinical progression and invasive treatment conversion

Inclusion criteria

• English speaking
• SRM patient with biopsy-confirmed RCC who are initiating or already on AS for less than 5 years
• Age 18 years or older
• Body mass index (BMI) ≥ 25 kg/m^2
• No medical problems that might contraindicate participation in a behavioral weight reduction program containing an exercise component
• No current medication that might affect weight loss
• Not pregnant or lactating
• No more than 5% body weight loss in the past 3 months
• No bariatric surgery in the last 10 years

Exclusion criteria

• Non-English speaking
• Less than 18 years old
• BMI < 25 kg/m^2
• Medical problems that might contraindicate participation in a behavioral weight reduction program containing an exercise component
• Current medication that might affect weight loss
• Pregnant or lactating
• More than 105% body weight loss in the past 6 months
• Bariatric surgery in the last 10 years
• Medical conditions that might contraindicate short-term fasting periods
• Unwilling or unable to follow protocol requirements
• Received an investigational agent within 30 days prior to enrollment