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NCT Number: NCT07557173

Comparing Three Rescue Bowel Preparation Regimens for Colonoscopy After Failed Cleansing

The goal of this clinical trial is to learn which rescue bowel preparation works best for adults who need a repeat colonoscopy after a previous bowel preparation did not clean the bowel well enough. The study will also look at how satisfied participants are with each preparation. The main questions it aims to answer are:

* Which bowel preparation helps more participants achieve adequate bowel cleansing before repeat colonoscopy? * Which bowel preparation leads to better cleansing in different parts of the colon? * Which bowel preparation is better tolerated by participants?

Researchers will compare 3 rescue bowel preparation regimens to see which one works best for repeat colonoscopy after a previous cleansing failure.

Participants will:

* be randomly assigned to 1 of 3 bowel preparation regimens * take one of the following regimens before repeat colonoscopy: * 4 liters of polyethylene glycol (PEG) plus 12 milligrams of bisacodyl * 1 liter of PEG plus ascorbic acid plus 10 milligrams of bisacodyl * 2 liters of PEG plus extra PEG taken over the 3 days before colonoscopy * undergo repeat colonoscopy * rate their satisfaction with the bowel preparation

Recruiting

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Key information

Conditions

Bowel Cleansing for Colonoscopy Inadequate Bowel Preparation

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adults aged 18 years or older
  • Prior inadequate bowel preparation (adequately performed) requiring repeat colonoscopy
  • Scheduled to undergo repeat outpatient colonoscopy
  • Ability to provide informed consent

Exclusion criteria

  • Age younger than 18 years
  • Inability to provide informed consent
  • Contraindication to any study bowel preparation regimen or colonoscopy
  • Known or suspected bowel obstruction or severe gastrointestinal motility disorder
  • Pregnancy or breastfeeding
  • Participation considered inappropriate by the investigators for clinical or safety reasons

Treatment and study plan

Drug

Drug

4 liters of polyethylene glycol plus bisacodyl 12 mg administered as rescue bowel preparation before repeat colonoscopy.

Other names: SELG ESSE, Bisacodyl

Primary outcomes

  1. Adequate bowel preparation at repeat colonoscopy

    Time frame: At repeat colonoscopy, on the day of the procedure

    Proportion of participants with adequate bowel preparation at repeat colonoscopy, defined as a Boston Bowel Preparation Scale (BBPS) total score of 6 or higher, with a score of at least 2 in each colonic segment.

Secondary outcomes

  1. Total Boston Bowel Preparation Scale score at repeat colonoscopy

    Time frame: At repeat colonoscopy, on the day of the procedure

    Mean total Boston Bowel Preparation Scale (BBPS) score assessed at repeat colonoscopy. The BBPS ranges from 0 to 9, with higher scores indicating better bowel cleansing.

  2. Right colon Boston Bowel Preparation Scale subscore

    Time frame: At repeat colonoscopy, on the day of the procedure

    Mean BBPS subscore for the right colon assessed at repeat colonoscopy. Segment scores range from 0 to 3, with higher scores indicating better bowel cleansing.

  3. Transverse colon Boston Bowel Preparation Scale subscore

    Time frame: At repeat colonoscopy, on the day of the procedure

    Mean BBPS subscore for the transverse colon assessed at repeat colonoscopy. Segment scores range from 0 to 3, with higher scores indicating better bowel cleansing.

  4. Left colon Boston Bowel Preparation Scale subscore

    Time frame: At repeat colonoscopy, on the day of the procedure

    Mean BBPS subscore for the left colon assessed at repeat colonoscopy. Segment scores range from 0 to 3, with higher scores indicating better bowel cleansing.

  5. Participant satisfaction with bowel preparation

    Time frame: Assessed after bowel preparation and before or at repeat colonoscopy, on the day of the procedure

    Participant-reported satisfaction with the assigned bowel preparation regimen, measured using a numerical rating scale. Higher scores indicate greater satisfaction.

  6. Polyp detection at repeat colonoscopy

    Time frame: At repeat colonoscopy, on the day of the procedure

    Proportion of participants with at least 1 polyp detected during repeat colonoscopy.

Study contacts

Contact information is provided by the study sponsor or research team.

Giuseppe Scaglione

CONTACT

[email protected]

+39 360638237

Sponsors and collaborators

Lead sponsor

Ospedale San Pio

Other

Registry information

Official study title

Comparison of Three Different Rescue Bowel Preparation Regimens in Patients With Previous Bowel Cleansing Failure at Colonoscopy

Important dates

Study start
2024
Primary completion
2026
Study completion
2026
First posted
Apr 29, 2026
Registry last updated
May 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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