Comparing the Outcome of Buccal Midazolam and Intramuscular Midazolam in Children Presenting With Seizures.

• Introduction:

Generalised convulsive seizure is a serious and potentially life threatening medical emergency that requires prompt intervention. Administration of buccal midazolam is an efficient and easier method for control of seizures without the need for intravenous cannulation expertise or intramuscular injections.

• Objectives:

To compare the outcome of buccal midazolam versus intramuscular midazolam in children presenting with seizures.

• Study Design:

It is RCT

• Settings:

Pediatric Medicine Department, PAF hospital, Islamabad

• Study Duration:

15th January 2022 to 14th July 2022

• Materials & Methods: A total of 90 patients of both genders, 6 months to 12 years of age, presenting with seizures were included. Children with cardiac arrest or haemodynamic instability at presentation, head trauma or drowning, metabolic disorders, CKD were excluded.

All the patients were divided into two groups by lottery method.

In group A, children were given intramuscular midazolam in the thigh at 0.05 ml/kg (maximum 1.6 ml).

In group B, children were given buccal midazolam at 0.06 ml/kg (maximum 2 ml). They were followed till resolution of symptoms. If seizure resolved within 5 minutes, then success was labelled.

Inclusion criteria

• Children of age 6 months to 12 years, both genders, presenting with seizures (as per operational definition)
• Children with Seizure disorder, Febrile fits, Meningitis without raised intracranial pressure.

Exclusion criteria

• Children with cardiac arrest or hemodynamic instability at presentation, head trauma or drowning.
• Diagnosed cases of metabolic disorders, CKD.
• Diagnosed case of raised ICP.