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Completed

NCT Number: NCT06802484

Comparing the Effects of Multicomponent Exercise on Cardiovascular Health and Lipid Profiles in Premenopausal and Postmenopausal Women

Background: The present study aimed to examine the effects of a 26-week multicomponent exercise program on lipid and lipoprotein profiles, blood pressure, and anthropometric parameters in healthy but sedentary premenopausal and postmenopausal women aged 40-60.

Method: The program, comprising resistance, balance, flexibility, and aerobic exercises, aimed to identify group-specific responses and establish the program's efficacy in mitigating cardiovascular risks. Seventy-five women were recruited, and 38 completed the intervention. Participants were categorized into premenopausal (n=18), postmenopausal (n=10), and control groups (n=10). Key measures included total cholesterol, low- and high-density lipoprotein cholesterol, triglycerides, glucose, systolic and diastolic blood pressure, and anthropometric variables. Statistical analyses employed the Shapiro-Wilk test, paired t-tests, Wilcoxon tests, and Kruskal-Wallis tests, with α=0.05.

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Key information

Conditions

Menopause Cardiovascular

Age range

40 year–60 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Bruno Figueira

Evora, Portugal

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • women aged between 40 and 60 years old;
  • healthy, asymptomatic, and non-smoking;
  • medical diagnosis favouring the engagement in physical-sporting activities;
  • absence of clinical history related to alcoholism or uncontrolled metabolic disease;
  • no clinical prescription for hypotensive pharmacological intake, cholesterol reduction, hormonal replacement therapy, or any other intervention capable of inducing alterations in lipid and lipoprotein metabolism; or
  • abnormal blood sample results.

Exclusion criteria

  • non-fulfilment of inclusion criteria;
  • clinical history characterized by symptoms related to cardiovascular disease (CVD), including stroke (CVA) and coronary vascular disease (CVD), renal or hepatic disease, musculoskeletal disorders, or rheumatoid conditions that may impede full participation in the exercise program.

Treatment and study plan

Experimental: Pre-Menopausic

Other

The physical exercise program, lasting for 26 weeks, was conducted with an uninterrupted weekly frequency of 3 sessions, on non-consecutive days, in the late afternoon (at 7:30 PM), each lasting 60 minutes.

Experimental: Post- Menopausic

Other

The physical exercise program, lasting for 26 weeks, was conducted with an uninterrupted weekly frequency of 3 sessions, on non-consecutive days, in the late afternoon (at 7:30 PM), each lasting 60 minutes.

Primary outcomes

  1. Total Cholesterol

    Time frame: 26-week

  2. Low-density lipoprotein Cholesterol

    Time frame: 26-week

  3. High-density lipoprotein Cholesterol

    Time frame: 26-week

  4. Triglycerides

    Time frame: 26-week

  5. Castelli Risk Index I

    Time frame: 26-week

  6. Castelli Risk Index II

    Time frame: 26-week

  7. Very Low-Density Lipoprotein Cholesterol

    Time frame: 26-week

  8. Glucose

    Time frame: 26-week

  9. Systolic Blood Pressure

    Time frame: 26-week

  10. Diastolic Blood Pressure

    Time frame: 26-week

  11. Heart Rate

    Time frame: 26-week

  12. Body Mass Index

    Time frame: 26-week

  13. Waist Circumference

    Time frame: 26-week

  14. Hip Circumference

    Time frame: 26-week

  15. Waist Circumference/ Hip Circumference

    Time frame: 26-week

Sponsors and collaborators

Lead sponsor

University of Évora

Other

Registry information

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
Jan 31, 2025
Registry last updated
Jan 31, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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