Comparing the Effects of Exercise on the Structure and Function of Fat Tissue

Assess differences in structure and biological function of abdominal subcutaneous adipose tissue samples collected from adults who exercise regularly vs. a well-matched cohort of non-exercisers.

Completed

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Key information

Conditions

Adiposity Body Weight Nutrition Disorders Nutritional and Metabolic Diseases Obesity Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

University of Michigan

Ann Arbor, Michigan, 48109, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Age: 18-40 years old
Body Mass Index: 23-35 kg/m2
Women must have regularly occurring menses and must be premenopausal

Exclusion criteria

Evidence/history of cardiovascular or metabolic disease
Medications known to affect lipid or glucose metabolism, or inflammation
Weight instability ≥ ± 6 pounds in the last 6 months
Tobacco or e-cigarette users
Women must not be pregnant or actively lactating
Blood pressure > 140/90 mmHg

Treatment and study plan

Oral glucose tolerance test

Diagnostic Test

Subjects will complete an Oral Glucose Tolerance Test in which glucose is given and blood samples are taken every 15 minutes over a 2 hour period to determine how quickly the glucose is cleared from the blood.

Primary outcomes

Blood Glucose Level

Time frame: 2 hours at Experimental Trial

mg/dL
Adipose tissue fibrosis

Time frame: baseline

Pico-sirius Red stain (percent stained)

Sponsors and collaborators

Lead sponsor

University of Michigan

Other

Registry information

Official study title

Effects of Exercise Training on the Structure and Metabolic Function of Fat Tissue

Acronym: CAT

Important dates

Study start: 2020
Primary completion: 2023
Study completion: 2024
First posted: Apr 14, 2022
Registry last updated: Jun 29, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed