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OpenTrials
Completed

NCT Number: NCT06640465

Comparing the Effects of Commercially Available Dietary Supplements on CoQ10 Concentrations

The primary purpose of this study is to compare the safety and effectiveness of commercially available dietary supplements believed to increase coenzyme Q10 (CoQ10) concentrations.

An 8-week, randomized, placebo-controlled clinical trial will be conducted comparing the effectiveness of four commercially available dietary supplements on increasing CoQ10 concentrations and self-reported health outcomes.

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Key information

Conditions

Wellness Health

Age range

40 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

True Health Center for Precision Medicine, El Dorado Hills, California, United States

Loading trial locations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Adult males or females age ≥ 40 years
  • Ability to read and speak English

Exclusion criteria

  • Daily use within the past 2 months of any dietary supplements containing CoQ10 or geranylgeraniol (GG)
  • Taking a statin medication within the past 6 months
  • Current daily usage of H2 blockers or PPI medications
  • Current daily use of bisphosphonates
  • Current daily tobacco smoker
  • Known allergies to any substance in the study products
  • Currently pregnant or lactating women or women planning to become pregnant in the next 12 weeks
  • Current diagnosis of a chronic health condition (e.g., cancer, Crohn's disease) deemed clinically contraindicated for the study protocol.
  • Participant in a clinical trial in the previous 30 days.
  • Participants unable to provide consent

Treatment and study plan

Ubiquinol + geranylgeraniol

Dietary Supplement

Combination of ubiquinol and geranylgeraniol

Geranylgeraniol

Dietary Supplement

Geranylgeraniol alone

ubiquinol

Dietary Supplement

Ubiquinol alone

Ubiquinone

Dietary Supplement

Ubiquinone alone

Placebo

Other

Placebo capsule

Primary outcomes

  1. Plasma Coenzyme Q10

    Time frame: Baseline and 8 weeks

Secondary outcomes

  1. Comprehensive metabolic panel

    Time frame: Baseline and 8 weeks

    Alanine aminotransferase (ALT) in units per liter (U/L)

  2. Lipid panel

    Time frame: Baseline and 8 weeks

    Low-density lipoprotein (LDL) in milligrams per deciliter (mg/dL)

  3. Patient-Reported Outcomes Measurement Information System (PROMIS) - Global Health

    Time frame: Baseline and 8 weeks

    Raw scores range from 4 to 20, with higher scores indicating better global physical or mental health compared to the average

  4. Profile of Mood States - Vigor Subscale

    Time frame: Baseline and 8 weeks

    Scores range from 0 to 32, with higher scores indicating better energy levels

  5. Short Form 36 (SF-36) - Vitality Subscale

    Time frame: Baseline and 8 weeks

    Scores range from 0 to 100, with higher scores indicating greater vitality

Sponsors and collaborators

Lead sponsor

OvationLab

Network

Registry information

Official study title

A Randomized, Placebo-Controlled Trial Comparing the Effects of Commercially Available Dietary Supplements on CoQ10 Concentrations

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Oct 15, 2024
Registry last updated
Mar 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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