Comparing the Effect of the Water Drinking Test on Intraocular Pressure

A test that was common in the 1960's and was used to detect primary open angle glaucoma was the water drinking test (patients drank 1 quart of water to stress the fluid drainage mechanism of the eyes. Intraocular pressure was then measured over the next hour). Recently this test has been demonstrated as a predictor of peak eye pressure during the day. The purpose of this study is to compare the results of the water drinking test between eyes that have undergone trabeculectomy and eyes that have undergone tube shunt surgery.

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Key information

Conditions

Glaucoma Eye Diseases Ocular Hypertension

Age range

21 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Wills Eye Hospital

Philadelphia, Pennsylvania, 19107, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

prior trabeculectomy or tube shunt for the treatment of glaucoma
age 21-90 years

Exclusion criteria

inability to give informed consent
current ocular infection
more than 1 prior trabeculectomy, or more than 1 prior tube shunt
previous refractive surgery
pregnant women
heart failure
renal failure or uncontrolled urine retention
corneal abnormalities preventing reliable IOP measurement

Treatment and study plan

Water Drinking Test

Procedure

The Water Drinking test has been identified as a reliable and safe tool to predict maximum intraocular pressure values during a diurnal tension curve and to assess the efficacy of surgical interventions. Participants are asked to drink 10 ml/kg water (or approximately 0.33 ounces of water for every 2.2 pounds of weight or about 2.5 cups for a 150 lb. individual) over 15 minutes. Intraocular pressure is assessed every 15 minutes for one hour.

Primary outcomes

Intraocular Pressure (IOP)

Time frame: 1 hour

IOP is assessed every 15 minutes for one hour after the water drinking test is complete.

Sponsors and collaborators

Lead sponsor

Wills Eye

Other

Registry information

Official study title

Comparing the Effect of the Water Drinking Test on Intraocular Pressure in Patients With Prior Trabeculectomy or Tube Shunt Surgeries

Important dates

Study start: 2013
Primary completion: 2014
Study completion: 2014
First posted: Dec 4, 2013
Registry last updated: Nov 10, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

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