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NCT Number: NCT07180849

Comparing the Antiplaque Effects of Novel Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients.

In this study the investigators aimed to explore the antibiofilm effect of fluoride varnish loaded with titania nanoparticles synthesized from moringa oleifera leaves extract vs conventional fluoride varnish in multibracket fixed orthodontic patients.

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Key information

Conditions

Dental Plaque Accumulation Fluoride Varnishes Nanoparticles

Age range

16 year–30 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients planned for fixed orthodontic treatment.
  • Patients within age group 16-30 years.
  • Patient with no history of previous orthodontic treatment.
  • Patients with no active periodontal diseases.

Exclusion criteria

  • Patient undergoing any antibiotic therapy.
  • Patients with any craniofacial abnormality.
  • Patient with mixed dentition

Treatment and study plan

Fluoride varnish

Procedure

Group A will receive conventional fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index.

Novel titania nanoparticle infused fluoride varnish

Procedure

Group B will receive topical application of titania nanoparticle infused fluoride varnish for antiplaque effects.Plaque will be assessed quantitatively by modified plaque index.

Primary outcomes

  1. To compare the plaque inhibitory effect of titania nanoparticle infused fluoride varnish and conventional fluoride varnish in fixed orthodontic patients.

    Time frame: 6 months

    Plaque will be assessed quantitatively by modified plaque index.

Secondary outcomes

  1. To measure plaque bacterial load and pH following application of titania nanoparticle infused and conventional fluoride varnish in fixed orthodontic patients.

    Time frame: 6 months

    Bacterial colonies will be morphologically identified and counted as Colony Forming Units (CFU) using a colony counting grid.

Sponsors and collaborators

Lead sponsor

Pakistan Institute of Medical Sciences

Other Gov

Registry information

Official study title

Comparing the Antiplaque Efficacy of Titania Nanoparticle Infused Fluoride Varnish vs Conventional Fluoride Varnish in Fixed Orthodontic Patients-A Triple Blind Randomised Controlled Trial.

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Sep 18, 2025
Registry last updated
Sep 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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