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NCT Number: NCT07239999

Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty

This study or clinical trial looking to compare 2 types of freezing medications injected into the spinal fluid at the lower back between the vertebrae in patients going to have total knee replacement surgery to check for early legs movement, early discharge from recovery room, walking and hospital discharge. This could save hospital cost of such procedures.

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Key information

Conditions

Recovery Period Anesthesia

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I-III
  • Elective outpatient TKA
  • BMI less than 40
  • Ability to provide surgical consent

Exclusion criteria

  • Patient refusal
  • Opioid tolerant
  • Any contraindications to spinal anesthesia
  • Chronic opioid use 3months or more

Treatment and study plan

Mepivacaine Injection

Drug

Comparing time to motor block recovery in PACU, time to PACU discharge, time to ambulation and length of hospital stay

Chloroprocaine Injection

Drug

Comparing time to motor block recovery in PACU, time to PACU discharge, time to ambulation and length of hospital stay

Primary outcomes

  1. Time to complete recovery of motor block

    Time frame: Time from the intrathecal drug injection to the first documented instance of complete motor block recovery Bromage 0. Within approximately 2 hours for the Chloroprocaine group and 4 hours for the Mepivacaine group.

  2. Time to complete motor block recovery of lower limbs after spinal anesthesia

    Time frame: From the time of intrathecal drug injection to PACU discharge. Within approximately 3 hours for the Chloroprocaine group and 5 hours for the Mepivacaine group.

    Motor block will be assessed by PACU nurses in PACU using standard Bromage motor scale.

Study contacts

Contact information is provided by the study sponsor or research team.

HUSAM M NASHNOUSH, MBBCH, FRCPC

CONTACT

[email protected]

001-902-410-9062

Mohamed H Nashnoush, MED2

CONTACT

[email protected]

001-902-266-6010

Sponsors and collaborators

Lead sponsor

Nova Scotia Health Authority

Other

Registry information

Official study title

Randomized Controlled Trial Comparing Spinal Anesthesia With 1% Chloroprocaine Versus 1% Mepivacaine in Patients Undergoing Outpatient Primary Total Knee Arthroplasty

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Nov 20, 2025
Registry last updated
Feb 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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