Comparing Short to Standard Amoxicillin Course for Erysipelas

Inclusion criteria

• Patients ≥ 18 years
• Affiliated to a social security scheme
• Who have given written consent according to local regulatory requirements after the nature of the study has been explained to them, and prior to any protocol specific procedures being performed,
• Clinical signs of lower limbs erysipelas ≤ 5 days defined as:

o Warmth, erythema, edema (induration of the skin and/or subcutaneous tissue) and/or pain (NRS≤8)

• Shiver, feverish sensation or fever experienced by the patient ≤ 5 days or fever measured by the physician ≥ 38°C
• Severity score ≥ 3 scored on three criteria: edema, erythema, pain with the following scales (0= none, 1=moderate, 2=severe)
• Absence of erysipela ≤ 12 months
• Absence of blisters
• Absence of solid purpura (purple tablecloth not erasing at vitro-pressure)
• Absence of cutaneous necrosis
• Absence of crepitation (crepitation = perception identical to that of cutaneous emphysema

Exclusion criteria

• Allergy to ß lactam, fructose intolerance
• Weight < 40 kg or > 105 kg
• Use of oral antibiotic within 5 days (excluding one or two antibiotic intake ≤ 24 hours)
• Erysipela/Cellulitis requiring hospitalization
• Bilateral erysipela
• Abscess
• Lymphedema requiring permanent contention
• Animal bite ≤ 7 days
• HIV positive
• Patient with comorbidity: known active hepatitis, chronic kidney failure or hepatocellular insufficiency
• Patient unable to temporarily stop a long-term treatment as antibiotics or corticosteroids, or NSAIDs
• Patient under immunosuppressive or oncologic treatments ≤ 6 months
• Pregnant women or breastfeeding
• Patient under guardianship or curatorship, legal protection or protection of justice
• Participation in other Clinical Trial, interventional study, investigational study or performance study Any medical, mental, psychological or psychiatric condition considered by the investigator as compromising patient completion or understanding of the study