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Completed

NCT Number: NCT03355833

Comparing Prognostic Performance of SEPSIS 2 and SEPSIS 3 Strategies at the Emergency Service

In 2016, the Third International Consensus proposed a new strategy to screen aggravating risk in patients with septic shock. This strategy is based on quick-SOFA and the SOFA score. The main objective is to compare the prognostic performance of SEPSIS 3 against the previous strategy SEPSIS 2 to predict the admission in intensive care unit or the intra-hospital death.

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Key information

Conditions

Sepsis Infections Inflammation Pathologic Processes Pathological Conditions, Signs and Symptoms Systemic Inflammatory Response Syndrome

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

About this study

This study compare the prognostic performance of two strategies. It's a monocentric, retrospective study in patients admitted to the emergency department.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged of 18 years or more
  • Initiation of one or more antibiotics in the Accident and Emergency Department in the Metz-Thionville hospital (CHR) site Mercy, for curative purpose, regardless of the infectious aetiology
  • Hospitalized in the CHR Metz-Thionville thereafter

Exclusion criteria

  • Minors patients
  • Absence of antibiotic treatment initiated in the Emergency department
  • Prescription of antibiotic treatment in the emergency department for preventive purpose
  • Transferred by hospitalisation service of CHR Metz-Thionville in the emergency department
  • Absence of hospitalisation following their passage through the emergency department
  • Transferred to hospitalisation in an other establishment
  • Presence, at the admission, of an antibiotic treatment
  • Patients deceased in the emergency department

Treatment and study plan

Primary outcomes

  1. Intrinsic and Extrinsic properties of SEPSIS 3 strategy

    Time frame: Day 1

    The percentage of patients with high qSOFA score (2 or more) who were admitted in intensive care unit or who have died during their stay in hospital and rather the percentage of patients with a small qSOFA score who survived without passing through intensive care unit

Secondary outcomes

  1. Correlation between lactate levels and mortality

    Time frame: Day 1

    lactate levels at their admission

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Régional Metz-Thionville

Other

Registry information

Acronym: StraSEP

Important dates

Study start
2016
Primary completion
2016
Study completion
2016
First posted
Nov 28, 2017
Registry last updated
Aug 24, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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