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Completed

NCT Number: NCT06413472

Comparing Mechanical Power in Different Inspiratory Times

We aimed to compare mechanical power and energy values using geometric methods at varying inspiratory rise times.

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Key information

Conditions

Ventilator-Induced Lung Injury Acute Respiratory Distress Syndrome Lung Diseases Lung Injury Respiration Disorders Respiratory Distress Syndrome Respiratory Tract Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Basaksehir Cam Sakura City Hospital

Istanbul, Turkey (Türkiye)

About this study

In this study, the researchers aim to compare the mechanical power and energy values calculated using the geometric method in Volume-Controlled Ventilation (VCV) and Pressure-Controlled Ventilation (PCV) modes at different inspiratory rise times.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ARDS (Acute Respiratory Distress Syndrome) patients.
  • Patients who are deeply sedated.
  • Patients ventilated in:
  • Pressure-Controlled Ventilation (PCV or PRVC) mode, or
  • Volume-Controlled Ventilation (VCV) mode.
  • Patients within the 24-48 hour period of their stay in the intensive care unit.

Exclusion criteria

  • Patients with incomplete data.
  • Patients diagnosed with:
  • COPD (Chronic Obstructive Pulmonary Disease),
  • Heart failure.
  • Pregnant patients.
  • Patients with a thoracopleural fistula.
  • Hemodynamically unstable patients.

Treatment and study plan

Mechanical ventilator adjustment for PCV

Procedure

In pressure control ventilation (PCV) mode, patients will be ventilated for 5 minutes at a Tslope of 5% and another 5 minutes at 15% for both 1:1 and 1:2 I:E ratios. After each adjustment, screenshots of the mechanical ventilator (P-V loop screenshots) will be obtained . A total of 20 P-V loop screenshots will be captured over a 20-minute period (10 for the 1:2 ratio and 10 for the 1:1 ratio), which will be stored in the ventilators memory. The stored data will then be transferred from the ventilators memory to a computer via a flash drive.

Mechanical ventilator adjustment for VCV

Procedure

In volume control ventilation (VCV) mode, patients will be ventilated for 5 minutes at a Tslope of 5% and another 5 minutes at 15% for both 1:1 and 1:2 I:E ratios. After each adjustment, screenshots of the mechanical ventilator (P-V loop screenshots) will be obtained . A total of 20 P-V loop screenshots will be captured over a 20-minute period (10 for the 1:2 ratio and 10 for the 1:1 ratio), which will be stored in the ventilators memory. The stored data will then be transferred from the ventilators memory to a computer via a flash drive.

Primary outcomes

  1. MPgeo

    Time frame: 40 minute

    The mechanical power (MPgeo) values measured using the geometric method .

  2. Energy

    Time frame: 40 minute

    Energy values measured using the geometric method .

Sponsors and collaborators

Lead sponsor

Başakşehir Çam & Sakura City Hospital

Other Gov

Collaborators

  • SBÜ Dr. Sadi Konuk Eğitim ve Araştırma Hastanesi

Registry information

Official study title

Comparing Mechanical Power Values Using Geometric Methods at Different Inspiratory Rise and Pause Times: A Validation Study

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
May 14, 2024
Registry last updated
Jul 28, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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