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OpenTrials
Completed

NCT Number: NCT01274039

Comparing Eye Pressure Using Maximal Tolerated Local Therapy or Systemic Acetazolamide

Local therapy for glaucoma is known to induce a conjunctival inflammation. Because of this, trabeculectomy is more likely to fail. The investigators exchange the local therapy by systemic therapy using acetazolamide and measure the eye pressure using local therapy and systemic therapy using acetazolamide. The investigators suspect an elevated eye pressure using acetazolamide compared to local therapy. In summary acetazolamide could be a better choice in reference to conjunctival inflammation, but a worse choice in reference to controlling eye pressure.

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Key information

Conditions

Control of Elevated Eye Pressure by Local and Systemic Therapy

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Cologne

Cologne, 50924, Germany

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with uncontrolled intraocular eye pressure
  • Patients with planed trabeculectomy in 3 to 4 weeks

Exclusion criteria

  • Patients not meeting the inclusion criteria
  • Patients with known intolerance to acetazolamide

Treatment and study plan

Acetazolamide for glaucoma patients to lower eye pressure

Drug

Acetazolamide tablets 3 times daily for 3 to 4 weeks

Primary outcomes

  1. Eye pressure

    Time frame: Once at the beginning of the study and once 3 to 4 weeks later

    The eye pressure is measured at the beginning of the study, when the patient is using the maximal tolerated local therapy and 3 to 4 weeks later, when using systemic acetazolamide treatment.

Sponsors and collaborators

Lead sponsor

University of Cologne

Other

Registry information

Official study title

Comparing Eye Pressure Using Maximal Tolerated Local Therapy or Systemic Acetazolamide. A Possible Pretreatment for Trabeculectomy Surgery.

Important dates

Study start
2009
Primary completion
2011
Study completion
2012
First posted
Jan 11, 2011
Registry last updated
Apr 15, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.