Comparing Efficacy and Safety of Steroid Withdrawal With Tacrolimus and MMF With Induction in Children After Kidney Transplantation

Comparing efficacy & safety of steroid withdrawal with tacrolimus, mycophenolate mofetil (MMF) with induction in children after kidney transplantation.

Inclusion criteria

• Male or female patient younger than 18 but not younger than 2 years of age
• Skeletal age of boys < or = 17, girls < or = 15 years
• Patient has end stage kidney disease
• Female patient of childbearing potential must have a negative serum pregnancy test prior to enrolment and must agree to practice effective birth control during the study and 6 weeks thereafter.
• The patient, or in case the patient is a minor, the patient's parent(s) or their legal representative, has been fully informed and has given written informed consent

Exclusion criteria

• Patient has a most recently measured panel reactive antibody (PRA) grade of > or = 50%
• Patient is allergic to or intolerant of study medication
• Patient and/or donor is known to be HIV positive.
• Patient has significant liver disease
• Patient with malignancy or history of malignancy
• Patient has previously received or is receiving an organ transplant other than kidney.
• Patient has been previously enrolled in this study.
• Patient with the relapsing and non-diarrhoeal form of haemolytic uraemic syndrome.