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Completed

NCT Number: NCT03360045

Comparing Effectiveness of Merocel and Packing With Tranexamic Acid in the Management of Anterior Epistaxis

Aim of this study is evaluate whether superior nasal compression with tranexamic acid to simple nasal compression and Merocel packing.

In this study, patients who presented with non-traumatic anterior epistaxis to emergency departments will be included in this study. Three different therapy option are created; first, nasal compression with tranexamic acid, second, simple nasal compression without any drugs. And third, packing with Merocel.

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Key information

Conditions

Tranexamic Acid Epistaxis Hemorrhage Nasal Packing Nose Diseases Otorhinolaryngologic Diseases Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Keçiören Training and Research Hospital

Ankara, 06000, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with anterior epistaxis older than 18 year and accept to participate in the study

Exclusion criteria

  • Patients younger than 18 years
  • Patients who used anticoagulation therapy
  • Patients who have hemodynamically instability
  • Traumatic epistaxis
  • Patients who have known bleeding disorder

Treatment and study plan

Tranexamic Acid

Drug

500mg tranexamic acid is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually.

normal saline

Drug

5 cc normal saline is sprayed in the nose by atomizer spray, and then is applied nasal compression by manually.

merocel

Device

Merocel packing is applied.

Primary outcomes

  1. Success rate of interventions to stop bleeding

    Time frame: First 15 minutes

    Percentages of numbers of patients who have stopped bleeding within first 15 minutes after nasal compression or Merocel packing

  2. Numbers of patients who needs rescue treatment

    Time frame: After 15 minutes first intervention method.

    In patients who have unstoppable epistaxis within 15 minutes, Merocel packing will be applied as a rescue treatment. Numbers of these patients will be recorded.

Secondary outcomes

  1. Re-bleeding

    Time frame: 24 hour

    Frequency of re-bleeding within first 24 hours.

Sponsors and collaborators

Lead sponsor

Kecioren Education and Training Hospital

Other

Registry information

Official study title

The Evaluation of Effectiveness of Nasal Compression With Tranexamic Acid Compared to Simple Nasal Compression and Merocel Packing

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Dec 2, 2017
Registry last updated
Aug 7, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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