Comparing Effect of Autologous Platelet-Rich Plasma Versus Hyaluronic Acid Treatment on Knee Osteoarthritis

In the PRP group, an Aeon Acti-PRP set was used and an approximately 4-mL PRP volume was yielded and was used in a single-dose treatment. In the HA group, HYAJOINT Plus containing 60 mg of purified sodium hyaluronate was used in a single-dose treatment. All PRP and HA injection syringes were covered with opaque envelop, and the intra-articular injection procedure was performed by the same physician without ultrasound or other imaging guidance.

Inclusion criteria

• patients older than 50 years
• a diagnosis of primary knee osteoarthritis
• Kellgren-Lawrence (K-L) grading scale smaller than 3
• both male and female.

Exclusion criteria

• patients younger than 50 years of age
• K-L grade 3 or more
• history or active presence of clinically significant inflammatory articular or rheumatic disease other than OA
• generalized OA
• the detection of rapidly progressive OA before the start of the trial
• underwent any previous lower extremity surgery
• excessive mechanical axis deviation (varus > 5°, valgus > 5°)
• body mass index larger than 30
• history or presence of malignant disorders
• systemic disorders such as diabetes mellitus, severe cardiovascular diseases, hematologic diseases, immune-deficiencies, and infections
• systematic or intra-articular corticosteroid therapy in the previous 3 months
• prior treatment with HA in the past 6 months
• anticoagulants or antiaggregants therapy in the preceding 30 days
• non-steroidal anti-inflammatory medications in the preceding 7 days
• platelet count less than 150,000/ml of blood
• hemoglobin values less than 12g/dL of blood.