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Completed

NCT Number: NCT03531580

Comparing Brain Images Before and After MRI-upgrade - TimFit Upgrade Study

In the Ghent University, an upgrade of the MRI-scanner used for research from Siemens Trio Tim to Siemens Prisma Fit is planned in the near future. As a change of MRI hard- and software might influence brain images, it is necessary to evaluate the images before and after the upgrade.

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Key information

Conditions

Neuroimaging Quality Control

Age range

20 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ghent University

Ghent, 9000, Belgium

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Healthy volunteer

Exclusion criteria

  • Protheses or artificial implants, no magnetic or metal parts in the body
  • Being pregnant or breastfeeding
  • Having claustrophobia

Treatment and study plan

Magnetic Resonance Imaging

Device

Brain imaging using magnetic resonance imaging, using several MRI sequences: structural imaging (grey matter, using T1-imaging), cerebral perfusion using arterial spin labeling), functional and effective connectivity (using resting-state functional MRI), white matter tracts (using diffusion imaging), white matter lesions (using Fluid-attenuated inversion recovery MRI (FLAIR)) and microbleeds (using Susceptibility weighted imaging (SWI))

Primary outcomes

  1. Change in grey matter volume before versus after MRI-upgrade

    Time frame: 7 months, 4 scan sessions of max 1 hour

  2. Change in cerebral perfusion (ml/100g/min) using Arterial Spin Labeling before versus after MRI-upgrade

    Time frame: 7 months, 4 scan sessions of max 1 hour

  3. Change in arterial transit times before versus after MRI-upgrade

    Time frame: 7 months, 4 scan sessions of max 1 hour

  4. Change in functional connectivity (fc) using Resting State functional MRI before versus after MRI-upgrade

    Time frame: 7 months, 4 scan sessions of max 1 hour

  5. Change in effective connectivity using resting state functional MRI before versus after MRI-upgrade

    Time frame: 7 months, 4 scan sessions of max 1 hour

  6. Change in white matter diffusion before versus after MRI-upgrade

    Time frame: 7 months, 4 scan sessions of max 1 hour

  7. Difference in image quality of FLAIR image before versus after MRI-upgrade

    Time frame: 7 months, 4 scan sessions of max 1 hour

  8. Difference in image quality of SWI image before versus after MRI-upgrade

    Time frame: 7 months, 4 scan sessions of max 1 hour

Sponsors and collaborators

Lead sponsor

University Ghent

Other

Registry information

Official study title

Brain Images Before and After Upgrade of the MRI-scanner (Siemens Tim TRIO vs Siemens PRISMA FIT) - The TimFit Study

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
May 21, 2018
Registry last updated
Dec 1, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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