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OpenTrials
Completed

NCT Number: NCT06990607

Compare PPV With and Without Silicone Oil in Managing Postoperative Endophthalmitis

Comparing PPV with and without silicone oil in managing postoperative endophthalmitis

Completed

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Key information

Conditions

Endophthalmitis Following Cataract Surgery

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Al-Azhar University

Cairo, Cairo Governorate, Egypt

About this study

The objective of this study is to compare the outcomes of PPV with silicone oil tamponade to PPV alone in patients with postoperative endophthalmitis by assessing visual acuity, and postoperative complications such as rhegmatogenous retinal detachment (RRD).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • adult patients (≥ 18 years) presenting with clinical manifestations of endophthalmitis after cataract surgery

Exclusion criteria

  • patients with concurrent ocular or systemic conditions that could potentially confound study outcomes, such as active retinal diseases unrelated to endophthalmitis
  • pre-existing poor visual prognosis due to conditions like advanced glaucoma or macular degeneration, or prior ocular surgery affecting the study

Treatment and study plan

pars plana vitrectomy

Procedure

Pars plana Vitrectomy using 23 Gauge

Silicone Oil

Procedure

Silicone Oil injection after PPV

Primary outcomes

  1. visual acuity, with best-corrected visual acuity (BCVA) recorded using LogMAR

    Time frame: 1, 2, 4, and 12 weeks postoperatively

    log-MAR value (log of the minimum angle of resolution). Normal visual acuity for most adults is approximately -0.1 on this scale, which is equivalent to 20/16 on a Snellen visual acuity chart.

Sponsors and collaborators

Lead sponsor

Benha University

Other

Registry information

Official study title

Pars Plana Vitrectomy With Silicone Oil Versus Pars Plana Vitrectomy Alone in the Management of Postoperative Endophthalmitis

Acronym: Endopthalmitis

Important dates

Study start
2024
Primary completion
2024
Study completion
2024
First posted
May 25, 2025
Registry last updated
May 25, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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