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Active, Not Recruiting

NCT Number: NCT07460869

Compare Between the Effect of CGF and PRF on Revascularization of Immature Roots of the Mandibular Permanent First Molar

in this study investigators do revascularization technique to promote root growth of immature mandibular first permanent molar by using CGF and PRF from blood sample of patients

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Revascularization of Immature Young Permenant Teeth

Age range

6 year–8 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Faculty of Dentistry Minya University

Minya, Minya Governorate, 2422998, Egypt

About this study

children 6-8 yrs were selected for this study because the roots of mandibular first permanent molar is not completed. then access cavity is opened, irrigation protocol is applied, intracanal medication is applied and the cavity is sealed with temporary filling. after three weeks blood sample is obtained from patients to get CGF and PRF membranes. temporary filling is removed . intracanal medication is removed, over instrumentation is done to get some intracanal blood the wait tell blood clot is formed then CGF or PRF is applied on the clot the bio dentine is applied and cavity is sealed with composite restoration

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Children with immature necrotic lower fitrst permanent molar.
  • No history of repeated pathosis or cellulitis.
  • Patients accept the treatment modality.
  • Patient-free from systemic, allergic or genetic problems.

Exclusion criteria

  • Tooth mobility.
  • Teeth with non-restorable crowns.
  • Children with facial cellulitis
  • Children with draining fistula
  • Children with a history of recurrent preapical pathosis

Treatment and study plan

Revascularization/Conservative management

Biological

Compare the effect of CGF and PRF in the revascularization of immature mandibular first permanent molar using bio-dentine

Primary outcomes

  1. root growth

    Time frame: 18 months

    change root length

Sponsors and collaborators

Lead sponsor

Minia University

Other

Registry information

Official study title

Concentrated Growth Factor Versus Platelets-rich Fibrin in Revascularization of Immature Necrotic Mandibular First Permanent Molar.

Important dates

Study start
2025
Primary completion
2026
Study completion
2027
First posted
Mar 10, 2026
Registry last updated
Mar 10, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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