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Completed

NCT Number: NCT05602038

Comparative Study on the Effect of Quadratus Lumborum Block Versus Intrathecal Morphine on the Incidence of Chronic Pain Post Caesarean Section

The aim of this study is to compare the incidence of CPSCP in patients receiving QLB quadratus lumborum block and ITM versus control as a primary outcome and associated risk factors that might predispose patients to develop CPSCP.

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Key information

Conditions

Chronic Post Cesarean Pain

Age range

18 year–45 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Menoufia University

Menoufia, 32817, Egypt

About this study

The aim of this study is to compare the incidence of chronic post cesarean pain in patients receiving quadratus laborum block and and intrathecal morphine versus control as a primary

Study design:

Patients will be randomly allocated to the procedure through closed envelopes and so syringes and medication will be prepared and labelled by anesthetist other than the anesthetist giving the block Patients will be randomly allocated to the procedure through closed envelopes and so syringes and medication will be prepared and labelled by anesthetist other than the anesthetist giving the block Data will be collected regarding the demographic data, gestational stage, parity and number of previous cesarean section, previous abdominal surgeries, and narcotic consumption.

Postoperative pain day 1 and day2 will be followed by anesthetist who is blinded to the applied technique used. Follow up for the subsequent period of observation (2,4and 6 months) will be done by the department secretary who will contact the patients by phone to ask them if there is any "concern" after the operation. If the patient refers to a pain at the surgical site that has been lasting for the past three months a call will be conducted by the anesthetist and a referral schedule will be appointed to the pain clinic consultant for further evaluation

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients admitted to the operating theatre for elective caesarean section

Exclusion criteria

  • lack of informed consent
  • Allergy to drugs used during the study
  • Depression and epilepsy that required antidepressants or anticonvulsants
  • known coagulopathy as a contraindication for spinal anesthesia

Treatment and study plan

Quadratus laborum block

Procedure

quadratus lumborum block will be performed using ultrasound machine (Sonosite Portable Ultrasound System, SonoSite, Bothell, Washington, USA). A 5-8 MHZ curved probe will be used with the patient positioned on the lateral side

Intrathecal morphine

Drug

Intrathecal morphine 100mcg will be added to bupivacaine 0.5% 15mg and fentanyl 20 µg

Intrathecal Bupivacaine

Drug

intrathecal bupivacaine 0.5% 15mg and fentanyl

Primary outcomes

  1. Visual analogue scale

    Time frame: Six months

    As zero is no pain and 10 is the maximum pain that can be felt

Secondary outcomes

  1. narcotic consumption

    Time frame: 48 hours

    narcotic consumption

Sponsors and collaborators

Lead sponsor

Menoufia University

Other

Registry information

Official study title

Quadratus Lumborum Block Versus Intrathecal Morphine for Prevention of Chronic Post-Caesarean Pain: A Four-Arm Randomised Controlled Trial

Important dates

Study start
2023
Primary completion
2023
Study completion
2023
First posted
Nov 1, 2022
Registry last updated
May 14, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.