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Completed

NCT Number: NCT02722252

Comparative Study of Two Embryo Culture Systems

The centre for Medically-Assisted Procreation (MAP) of Dijon CHU has two high-technology embryo culture systems, with incubation characteristics that are potentially superior to those provided by classical culture systems. Indeed, these two systems, available in only two MAP centres in France, make it possible to maintain a stable temperature and gaseous environment during the in-vitro development of the embryos.

It is necessary to observe the development of the embryos to determine which embryos have the highest implantation potential. These observations are done from time to time by microscope for one system and continuously using an incorporated video camera for the other (cinematographic study). The MAP centre in Dijon wishes to compare the interest of these two systems.

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Key information

Conditions

Infertility Genital Diseases Urogenital Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU de DIJON

Dijon, 21079, France

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Persons who have provided oral consent
  • Attempt at In Vitro Fertilization with ICSI (IntraCytoplasmic Sperm Injection)
  • At least 6 mature ovocytes to microinject

Exclusion criteria

  • Persons not covered by national health insurance
  • Attempt at In Vitro Fertilization (IVF)
  • Fewer than 6 mature ovocytes
  • Decision to transfer at the zygote stage during the multidisciplinary meeting
  • Attempts made in a context of viral risk (both systems are in a virus risk-free zone)
  • Attempts with surgically-harvested spermatozoa

Treatment and study plan

Embryoscope

Device

Embryo culture system without incorporated camera

Device

Primary outcomes

  1. Implantation rate

    Time frame: 16 weeks after transfer

    The implantation rate is defined as the number of embryos implanted (gestational sacs seen on the US scan) compared to the total number of embryos transferred.

Secondary outcomes

  1. Rate of miscarriages

    Time frame: 16 weeks after transfer

Sponsors and collaborators

Lead sponsor

Centre Hospitalier Universitaire Dijon

Other

Registry information

Official study title

Comparative Study of Two Embryo Culture Systems: Randomization of Attempts at In Vitro Fertilization With ICSI at the Centre for Medically Assisted Procreation at Dijon CHU

Acronym: INCUBATE

Important dates

Study start
2014
Primary completion
2017
Study completion
2017
First posted
Mar 29, 2016
Registry last updated
Feb 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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