Comparative Study of the Bioavailability of Magnesium Administrated by Two ChronoMag Smart Tablet® 50 mg Versus Three Mag2® Tablets 100mg.

" Go/no go " comparative biodisponibility study. Randomised, cross-over, controlled and double-blind, monocentric study in healthy volunteers.

Inclusion criteria

• Healthy male volunteers
• Patient aged between 18 and 50
• Patient with a normal blood magnesium rate between 0.65 and 1.05 mmol/l
• Patient with vital signs values considered as normal by the investigator before drug administration
• Sufficient cooperation and understanding to comply with the requirements of study.
• Patient without medication during the 7 days preceding the inclusion
• Acceptance to give a written consent.
• Affiliation at system of French social security.
• Inscription or acceptation of inscription at national register of voluntaries participant at research.

Exclusion criteria

• Against magnesium-indication: hypersensitivity known at carbonate or magnesium chloride or at one of the excipients.
• Patient with medication or supplementation of magnesium
• Severe renal insufficiency with a creatine clearance ≤ 30ml/min
• Medical and chirurgical history considered as incompatible with the study
• A progressive pathology during the inclusion
• A consumption of more than 50g of dark chocolate per day
• An excessive alcohol consumption, an excessive tobacco consumption ( more than 10 cigarettes a day), an excessive tea, coffee or drink with caffeine consumption or drug addictions
• Patient who participated in another clinical trial located in exclusion period or received benefits > 4500 euros during 12 months before the beginning of trial.
• Patient with cooperation and understanding insufficiency to comply with the requirements of protocol
• Minor or patient with social protection (curatorship, tutorship…)
• No affiliation at system of French social security