Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors

The main goal of this study is to follow patients with functional adrenal tumors during the time before and after their surgery.

The main questions it aims to answer are:

* What heart and blood pressure changes do patients with different types of adrenal tumors have before surgery? * What factors affect how the heart and blood pressure recover after surgery? * Do the heart and blood pressure conditions before surgery influence recovery and the risk of heart or brain problems after surgery?

Patients will have heart ultrasound checks and health monitoring before and after surgery. The results will help doctors choose the right medicines before surgery, better understand possible risks during the operation, and make safer treatment plans for patients with functional adrenal tumors.

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Key information

Conditions

Primary Aldosteronism Adrenal Gland Diseases Adrenal Gland Neoplasms Adrenal Tumor Adrenocortical Hyperfunction Cushing s Syndrome Endocrine Gland Neoplasms Endocrine System Diseases Hyperaldosteronism Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Germ Cell and Embryonal Neoplasms, Nerve Tissue Neuroectodermal Tumors Neuroendocrine Tumors Paraganglioma Pheochromocytoma Pheochromocytoma/Paraganglioma (PPGL)

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Peking University First Hospital

Beijing, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients diagnosed in the Department of Urology, Peking University First Hospital with pheochromocytoma and paraganglioma (PPGL), primary aldosteronism (PA), or Cushing syndrome (CS);
Written informed consent obtained.

Exclusion criteria

Patients with PPGL, PA, or CS who receive medication or conservative treatment and are not eligible for surgical resection;
Patients with communication disorders or severe physical impairments such as aphasia, or visual/hearing disabilities;
Patients with severe mental illness who cannot cooperate with the study;
Pregnant women or patients otherwise deemed unsuitable for participation by the investigators.

Treatment and study plan

Primary outcomes

Recovery of cardiac function after adrenal surgery

Time frame: from enrollment to 4,24,48 weeks after surgery

global longitudinal stress

Secondary outcomes

Recovery of blood pressure after adrenal surgery

Time frame: from enrollment to 4,24,48 weeks after surgery

Decrease in 24h average blood pressure

Sponsors and collaborators

Lead sponsor

Peking University First Hospital

Other

Registry information

Official study title

Dynamic Monitoring and Comparative Study of Perioperative Cardiac Injury in Patients With Functional Adrenal Tumors

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2026
First posted: Sep 19, 2025
Registry last updated: Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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