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NCT Number: NCT07548918

Comparative Study of Microneedling With Topical Minoxidil 5% ± NB-UVB in Stable Vitiligo"

This study is a randomized controlled trial comparing microneedling with topical minoxidil 5% versus microneedling with minoxidil combined with NB-UVB phototherapy in stable vitiligo.

It aims to evaluate both clinical and histopathological outcomes in 30 patients with non-segmental stable vitiligo.

Vitiligo is a chronic depigmenting disorder caused by melanocyte destruction with significant psychosocial impact.

The study also investigates immunohistochemical changes, particularly Wnt/β-catenin signaling expression in lesional skin.

The combination therapy is expected to enhance repigmentation by improving melanocyte activation, drug delivery, and angiogenesis

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Key information

Conditions

Vitiligo - Macular Depigmentation

Age range

16 year–60 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with stable non-segmental vitiligo
  • No new lesions
  • No enlargement of existing lesions
  • Patients of both sexes
  • Age 16 years or older

Exclusion criteria

  • Active vitiligo
  • Pregnant or lactating women
  • History of keloid formation
  • Hematological disorders
  • Coagulopathies
  • Use of anticoagulant therapy
  • Use of medications that may prolong bleeding
  • Previous vitiligo treatment in the last 2 months

Treatment and study plan

microneedling with minoxidil 5% and NBUVB

Combination Product

Micronnedlin depth 1% then topical Minoxidil5% and Narrow Band UVB

Microneedling with Minoxidil5%

Combination Product

Microneedling with topical Minoxidil 5%

Primary outcomes

  1. Repigmentation in the vitiliginous area after receiving the treatment and increasing the wnt b catenin marker level in the histopathological specimen

    Time frame: From enrollment to the end of treatment at 16 weeks for each patient

Study contacts

Contact information is provided by the study sponsor or research team.

Rasha Hesham el dein mohammed, Bachelor

CONTACT

[email protected]

+201111199719

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Comparative Clinical and Histopathological Study of Microneedling With Topical Minoxidil 5% Versus Microneedling With Topical Minoxidil 5% Combined With Narrow-Band Ultraviolet B Phototherapy in the Treatment of Stable Vitiligo

Important dates

Study start
2026
Primary completion
2027
Study completion
2027
First posted
Apr 23, 2026
Registry last updated
Apr 29, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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