Misr University for Science and Technology
Giza, Egypt
Location status: Recruiting
Location contact
Abeer Mohamed Kamal, Phd of OMFS
CONTACT
01005168009 ext. 002
Omnia Tarek Hosni, Bachelor Degree
PRINCIPAL_INVESTIGATOR
Recruiting
NCT Number: NCT07472192
Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With PDRN Versus Fractional CO₂ Laser
Facial scars are frequently deemed unpleasant and can profoundly impact a patient's psychological health. This study compares the effectiveness, safety, and capacity to speed up scar healing in the maxillofacial region between fractional carbon dioxide (CO₂) laser therapy alone and polydeoxyribonucleotide (PDRN) combined with CO₂ laser therapy.
Recruiting
Interested in participating?
Request InfoKey information
Conditions
Age range
18 year–50 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Phase 2
Primary location
Who can participate
Healthy volunteers accepted: No
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- Age Limitations: Participants must be between 18 and 50 years of age.
- Recently cut wounds or surgical scars from about (1-6 months).
- Consent to Participate: Willingness to provide informed consent and engage in all aspects of the study.
Exclusion criteria
- Pregnancy or breastfeeding at the time of study.
- Known allergy to PDRN.
- Medication use that could affect wound healing or inflammation, such as:
- Isotretinoin.
- Anticancer drugs.
- High-dose corticosteroids.
- Anticoagulants.
- Uncontrolled medical diseases (e.g., unstable diabetes, cardiac conditions).
Treatment and study plan
Polydeoxyribonucleotide
Drugintralesional PDRN injections
Fractional CO2 laser assisted PDT
DeviceFractional carbon dioxide (CO₂) laser therapy for facial scars
Other names: co2 laser
Primary outcomes
-
Vancouver Scar Scale
Time frame: 4 months
The study used the standard Vancouver Scar Scale, which evaluates four characteristics of scars:
Total Score Range: 0 (normal skin) to 13 (severe hypertrophic scar)
Study contacts
Contact information is provided by the study sponsor or research team.
Sponsors and collaborators
Lead sponsor
Misr University for Science and Technology
Other
Registry information
Official study title
Comparative Study for Facial Scar Remodeling Using Fractional Carbon Dioxide Laser Combined With Polydeoxyribonucleotide (PDRN) Versus Fractional CO₂ Laser: A Randomized Controlled Clinical Study
Acronym: PDRN CO2 LASER
Important dates
- Study start
- 2026
- Primary completion
- 2026
- Study completion
- 2026
- First posted
- Mar 16, 2026
- Registry last updated
- Mar 16, 2026
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
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