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NCT Number: NCT06532318

Comparative Study Between Platelet Rich Plasma and Steroid Injection in Trigger Finger Treatment

The goal of this clinical trial is to learn if platelet rich plasma works to treat early stage trigger finger in adults. It will also learn about the safety platelet rich plasma. The main questions it aims to answer are:

Does platelet rich plasma lower the pain associated with trigger finger of participants? Does it improve the hand grip strength and Q DASH score of participants? Researchers will compare platelet rich plasma to Depo-Medrol steroid (a known standard of care for early stage trigger finger) to see if platelet rich plasma works to treat early trigger finger.

Participants will:

Take platelet rich plasma or a depo-medrol steroid intralesional injection at recruitment into the intervention Visit the clinic once every 4 weeks for checkups and parameter measurements. Investigator will will keep a record of participants progress in symptom remission

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Key information

Conditions

Trigger Finger Disorder Muscular Diseases Musculoskeletal Diseases Tendinopathy Tendon Entrapment

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 3

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients who are 18year and above with mild or moderate trigger finger, who are willing to have intra-lesional administration of blood product.

No previous treatment for the affected finger.

Exclusion criteria

  • Previous steroid injection
  • Previous Surgery to that finger
  • Thrombocytopenic patients
  • Hand and finger contracture
  • Rheumatoid arthritis of the finger

Treatment and study plan

Platelet rich plasma

Biological

Freshly prepared autologus platelet rich plasma

Pfizer Depo-medrol

Drug

Methylprednisolone acetate 20mg/ml injection

Primary outcomes

  1. symptom resolution post injection

    Time frame: 3 months

    reduction of pain using VAS and absence snapping of finger

Secondary outcomes

  1. Hand grip strength

    Time frame: 3 month

    measured grip using hand dynamomter

  2. Q- DASH score

    Time frame: 3month

    11-item self reported disability questionnaire that consider upper extremity as one functional unit

Sponsors and collaborators

Lead sponsor

Obafemi Awolowo University Teaching Hospital

Other

Registry information

Official study title

Comparative Study Between Intralesional Injection of Platelet Rich Plasma and Intralesional Steroid for the Treatment of Trigger Finger in Black Patients

Important dates

Study start
2024
Primary completion
2024
Study completion
2025
First posted
Aug 1, 2024
Registry last updated
Aug 1, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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