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NCT Number: NCT07743879

Comparative Efficacy of Therapeutic Ultrasound and Neurodynamic Techniques for Carpal Tunnel Syndrome

This randomized controlled trial compares the efficacy of therapeutic ultrasound alone, neurodynamic techniques alone, and combined therapeutic ultrasound and neurodynamic techniques in patients with mild to moderate carpal tunnel syndrome.

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Key information

Conditions

Carpal Tunnel Syndrome (CTS) Carpal Tunnel Syndrome Cumulative Trauma Disorders Median Neuropathy Mononeuropathies Nerve Compression Syndromes Nervous System Diseases Neuromuscular Diseases Peripheral Nervous System Diseases Sprains and Strains Wounds and Injuries

Age range

18 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Ibb University

Ibb, nine, Yemen

About this study

This three-arm parallel-group randomized controlled trial evaluated the comparative efficacy of therapeutic ultrasound (US), neurodynamic techniques (ND), and combined US plus ND in 60 participants with mild to moderate carpal tunnel syndrome over a 6-week intervention period. The primary outcomes measured were pain intensity via visual analog scale (VAS) and symptom severity and functional status using the Boston Carpal Tunnel Questionnaire (BCTQ). Secondary outcomes evaluated nerve conduction parameters including distal motor latency (DML), sensory latency (SL), and sensory nerve action potential (SNAP) amplitude.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Clinical diagnosis of mild to moderate carpal tunnel syndrome confirmed by electrophysiological testing.
  • Age between 18 and 65 years.
  • Presence of symptoms (pain, numbness, tingling) for at least 3 months.

Exclusion criteria

  • History of previous carpal tunnel release surgery or wrist trauma.
  • Corticosteroid injection into the wrist within the past 3 months.
  • Cervical radiculopathy, polyneuropathy, or other upper extremity neurological disorders.
  • Pregnancy or lactation.
  • Contraindications to therapeutic ultrasound (e.g., active infection, metallic implants in the treatment area, malignant tumors).

Treatment and study plan

Neurodynamic techniques

Other

Median nerve neurodynamic mobilization (progressing from sliders to tensioners), 3 sets of 10 repetitions.

Primary outcomes

  1. Pain Intensity

    Time frame: Baseline and 6 weeks post-intervention

    Measure Description: Measured using the unabbreviated Visual Analog Scale (VAS). This scale ranges from 0 to 10 cm, where 0 represents no pain and 10 represents the worst imaginable pain. Higher scores indicate a worse outcome (greater pain intensity).

  2. Symptom Severity

    Time frame: Baseline and 6 weeks post-intervention

    Measure Description: Assessed using the unabbreviated Boston Carpal Tunnel Questionnaire Symptom Severity Scale (BCTQ-SSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (more severe symptoms).

  3. Functional Status

    Time frame: Baseline and 6 weeks post-intervention

    Measure Description: Assessed using Boston Carpal Tunnel Questionnaire Functional Status Scale (BCTQ-FSS). The scale ranges from 1 to 5, with higher scores indicating a worse outcome (greater functional disability/impairment).

Sponsors and collaborators

Lead sponsor

IBB University

Other

Collaborators

  • Al-Razi University

Registry information

Official study title

Comparative Study Of Ultrasound and Neurodynamic Technique For Patients With Carpal Tunnel Syndrome in Mild And Moderate Stag

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Aug 4, 2026
Registry last updated
Aug 4, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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