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NCT Number: NCT07484672

Comparative Effects of Periodized Circuit Training and Conventional Strength Training in Patients With Diabetes Type II

Patients with type II diabetes are at high risk of developing cardiovascular diseases due to increased blood sugar, inflammation, insulin resistance, and physical inactivity. The effectiveness of exercises in improving cardiopulmonary fitness have not been well documented and practiced in Pakistan. The objective of this study is to determine the comparative effects of Periodized circuit and strength training in improving cardiovascular fitness, pulmonary functions , quality of life and glycemic control in type II diabetes patients. The study will be a randomized clinical trial. Based on the inclusion and exclusion criteria participants will be divided into 2 groups, Group A and Group B. The study will be 6 weeks, 3 sessions per week (18 sessions). Group A will be asked to perform Periodized circuit training 45 min per session (20 min aerobic exercise with 10 min warm up and cool down) with moderate intensity, 10min break and 15 min of resistance exercise while Group B will follow Conventional strength training 45 min per session, 35 min of strength and endurance training with 10 min of warm up and cool down. The study outcomes measures will be pulmonary functions (FEV1. FVC, FEV1/FVC ratio) through digital spirometer quality of life through health-related quality of life (HRQOL) questionnaire , cardiopulmonary fitness ( heart rate, blood pressure, oxygen saturation through 6MWT) and Glycemic control through (BCM). The data will be assessed at baseline, daily after the interventions and end of the study. Data will be analyzed using IBM SPSS software version 23.

Key words: CT (Circuit training), CF (Cardiovascular fitness), PF (Pulmonary function), CST (Conventional strength training), CVD (cardiovascular disease), T2D (Type 2 diabetes), BCM (Blood Glucose Monitor)

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Key information

Conditions

Diabetes Mellitus, Type 2 Cardiovascular Diseases Diabetes Mellitus Endocrine System Diseases Glucose Metabolism Disorders Metabolic Diseases Nutritional and Metabolic Diseases

Age range

40 year–70 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

JPMC Hospital

Karachi, Sindh, 75510, Pakistan

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Both gender age between 40 to 70
  • Participants who are hemodynamically stable
  • Participants who don't have any orthopedic limitation and can perform test
  • Diagnosed diabetes type II for at least one year
  • HBA1C less than 10% insulin independent
  • Without limitations in gait or balance, Independent living in the community
  • Non-smokers

Exclusion criteria

  • Patients with any neurological or other systemic disease
  • Individuals who are already performing physical activity such as muscle strengthening exercises, aerobic training, yoga or Pilates in last 6 months.
  • Uncontrolled blood pressure
  • Pregnancy or lactation
  • Severe cardiac disease
  • Patients who went under surgery for cardiac condition.

Treatment and study plan

Group A: Periodized Circuit Training

Other

Group A: Periodized Circuit Training Protocol The participants in this group performed Periodized circuit training 45 min per session, 10 min break. Before start exercises patients performed 5 min warm up session then 20 min of aerobic exercise and 15 min of resistance exercise. The exercise session were, Walking, jogging, body weight, scissor exercise and lastly cool down session of 5 minutes

Group B: Strength and Endurance Exercise Training Protocol

Other

The participants in this group performed Conventional strength training 45 min per session, 10 min break. Before start exercises patients performed 5 min warm up session then 30 min of strength and endurance training. The exercise session were jogging or walking, Glute Bridge, prone back extension, and ankle planter flexion and lastly cool down session of 5 min.

Primary outcomes

  1. Cardiovascular Fitness

    Time frame: 6 weeks

    A 6-minute walk distance (6-MWD) in meters were performed to determine the cardiovascular fitness pre-post exercise

  2. Pulmonary Functions

    Time frame: 6 weeks

    Digital Spirometer is a common tool used to test pulmonary functions through measuring the volume of air a person can inhale and exhale, as well as how quickly they can do so. It helps in diagnosing and monitoring respiratory diseases, and other conditions that affect lung function. The reliability is usually good with test results reproducibility generally being above 90%. The validity is also well-defined since spirometry is rated as gold standard of measuring the lung functioning. FEV1, FVC, and FEV1/FVC ratio were measured pre-post exercise through digital spirometer

  3. HRQoL

    Time frame: 6 weeks

    HRQoL questionnaire were used to access quality of life of diabetes II patients pre-post exercise

  4. Glycemic Control

    Time frame: 6 weeks

    Blood glucose monitor device were used to check the glucose level, pre-post exercise

Sponsors and collaborators

Lead sponsor

Riphah International University

Other

Registry information

Official study title

Comparative Effects of Periodized Circuit Training And Conventional Strength Training on Cardiovascular Fitness, Pulmonary Functions, Health- Related Quality of Life and Glycemic Control in Patients With Diabetes Type II

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Mar 20, 2026
Registry last updated
Mar 20, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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