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NCT Number: NCT07467954

Comparative Effectiveness of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser in Skin Rejuvenation

Skin rejuvenation is an effort to improve skin condition from the signs of skin aging. Skin aging is a complex biological process influenced by intrinsic and extrinsic factors, leading to changes in the epidermis and dermis, including decreased collagen characterized by dermal thinning, as well as alterations in skin appearance such as laxity and wrinkles. Laser therapy is one of the treatment modalities for skin rejuvenation, aiming to induce neocollagenesis and collagen remodeling, resulting in dermal thickening and improvement in skin appearance. Fractional CO₂ laser is an ablative laser considered the gold standard therapy for skin rejuvenation, whereas Long Pulsed (LP) Nd:YAG 1064 nm is a nonablative laser that is also used for skin rejuvenation. To date, there have been no studies evaluating the comparative effectiveness between fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation. Therefore, research comparing the effectiveness of fractional CO₂ laser and LP Nd:YAG 1064 nm for skin rejuvenation is needed, assessed based on dermal thickness, skin elasticity, wrinkles, and Global Aesthetic Improvement Scale scores.

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Key information

Conditions

Skin Rejuvenation LASER

Age range

30 year–59 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hasan Sadikin General Hospital

Bandung, West Java, 40161, Indonesia

Location status: Recruiting

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Male and female patients with skin aging classified as Glogau scale II-III
  • Age 30-59 years.

Exclusion criteria

  • Pregnant or breastfeeding women.
  • Active smokers.
  • Individuals with high levels of sun exposure.
  • History of facial laser therapy, microdermabrasion, chemical peeling, botulinum toxin injection, microneedling, or skin booster injections within the past six months.
  • Use of oral isotretinoin within the past six months.
  • Use of topical retinoids or their derivatives, topical vitamin C, or other collagen-stimulating and skin-rejuvenating agents within the past two weeks.
  • Use of oral vitamin C, collagen-stimulating supplements, antioxidants, or hormone therapy with skin-rejuvenating effects within the past one month.
  • Presence of active facial skin inflammation.
  • History of keloid formation.
  • History of allergy to topical lidocaine anesthesia.

Treatment and study plan

Fractional CO₂ laser

Procedure

Fractional CO₂ laser was applied to one randomized side of the face in a split-face design for skin rejuvenation. Treatments were performed three times at one-month intervals. The laser delivers fractional ablative microthermal zones to stimulate dermal remodeling and collagen production. Treatment parameters were adjusted according to skin type and clinical indication.

Long-pulsed 1064-nm Nd:YAG laser

Procedure

Long-pulsed 1064-nm Nd:YAG laser was applied to the contralateral randomized side of the face in a split-face design for skin rejuvenation. Treatments were performed three times at one-month intervals. The laser delivers non-ablative dermal heating to stimulate collagen remodeling and improve skin texture and elasticity.

Primary outcomes

  1. Dermal Thickness

    Time frame: From enrollment to the end of treatment at 20 weeks

    Dermal thickness was assessed based on the two-dimensional area of the hyperechoic band that appears brighter than the epidermis on ultrasonography assessment.

  2. Skin Elasticity

    Time frame: From enrollment to the end of treatment at 20 weeks

    Skin elasticity was defined as the ability of the skin to return to its original shape after deformation caused by mechanical traction. It was measured using a skin elasticity meter, and the R (recovery) value was assessed at 8 evaluation points on the face.

  3. Wrinkles

    Time frame: From enrollment to the end of treatment at 20 weeks

    Lines or folds formed on the skin surface as a result of mechanical stress, skin dehydration, or repetitive muscular activity, and were evaluated using a facial skin analyzer

  4. Global Aesthetic Improvement Scale Scores

    Time frame: From enrollment to the end of treatment at 20 weeks

    A 5-point rating scale (1-5) used to measure the degree of aesthetic improvement in patients following a procedure.

Study contacts

Contact information is provided by the study sponsor or research team.

Ahmad R Ganiem, M.D., Ph.D

CONTACT

[email protected]

+62 878 2288 3773

Kartika Ruchiatan, M.D.

CONTACT

[email protected]

+62 811 247932

Sponsors and collaborators

Lead sponsor

Universitas Padjadjaran

Other

Registry information

Official study title

A Comparative Split-Face Study of Long-Pulsed 1064-nm Nd:YAG and Fractional CO₂ Laser for Skin Rejuvenation Based on Dermal Thickness, Skin Elasticity, Wrinkle Assessment, and Global Aesthetic Improvement Scale Scores

Important dates

Study start
2025
Primary completion
2026
Study completion
2026
First posted
Mar 12, 2026
Registry last updated
Mar 12, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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